| Association of visfatin with chronic kidney disease in a cohort of patients with and without diabetes. | |
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MedLine Citation:
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PMID: 21375196 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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OBJECTIVE: To evaluate association of serum visfatin with CKD secondary to diabetic nephropathy and to compare it with patients of CKD secondary to other risk factors. METHODS: Seventy eight individuals including 28 healthy controls and 50 patients of CKD were included in this study. Patients with CKD were further grouped based on etiology of CKD into diabetics and non-diabetics. Patients with type 1 diabetes mellitus, urinary tract infection, urolithiasis, liver cirrhosis, stroke, ischaemic heart disease, and rheumatoid arthritis were excluded. Measurement of Serum visfatin was done through EIA Kit (Phoenix pharmaceuticals Burlingame CA). RESULTS: Visfatin concentration was significantly high in patients with CKD compared to controls (8.7 +/- 4.7 vs. 5.2 +/- 3.3 p = 0.001). No significant difference in Visfatin concentrations between patients of CKD with and without diabetes was detected (9.2 +/- 5.5 vs. 8.3 +/- 3.2 p = 0.694). A significant negative correlation of visfatin with estimated GFR (r2= -0.383, p = 0.01) and a positive correlation with degree of proteinuria (p = 0.01) was observed. CONCLUSION: The present study confirms the association of visfatin with CKD, however further studies at molecular level to check its expression within renal tissue may clarify its definitive role in CKD |
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Authors:
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Nosheen Mahmood; Abdul Manan Junejo; Qamar Jamal; Rashid Awan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: JPMA. The Journal of the Pakistan Medical Association Volume: 60 ISSN: 0030-9982 ISO Abbreviation: J Pak Med Assoc Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2011-03-07 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7501162 Medline TA: J Pak Med Assoc Country: Pakistan |
Other Details:
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Languages: eng Pagination: 922-6 Citation Subset: IM |
Affiliation:
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Department of Pathology, Ziauddin University, Pakistan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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