| Association of ventricular ectopy with nuclear scintigraphic perfusion defects during dipyridamole stress testing. | |
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MedLine Citation:
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PMID: 9491948 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND HYPOTHESIS: No information is available regarding the significance of ventricular ectopic activity induced during dipyridamole nuclear scintigraphic stress testing. This study tested the hypothesis that dipyridamole-induced ventricular ectopy predicts a thallium-201 or technetium-99m sestamibi perfusion defect. METHODS: A group of 186 consecutive patients with premature ventricular contractions and/or couplets occurring during dipyridamole stress testing (ventricular tachycardia did not occur) was compared with a control group of 194 patients without ventricular ectopy during dipyridamole stress testing. RESULTS: The results indicated that ventricular ectopy induced during dipyridamole infusion occurred more frequently in patients demonstrating either a fixed or reversible perfusion defect on scintigraphic imaging (p < 0.01). The higher frequency of perfusion defects in this group of patients was attributable to a higher frequency of "fixed" compared with "reversible" defects (p < 0.05). This finding is consistent with the additional observation that ventricular ectopy induced by dipyridamole was associated with the presence of Q waves on the resting ECG (p < 0.05). The positive and negative predictive values of the presence of ventricular ectopy in predicting a fixed myocardial perfusion defect were 59 and 54%, respectively. CONCLUSIONS: Ventricular ectopy induced during dipyridamole infusion suggests the presence of a fixed myocardial perfusion defect. |
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Authors:
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D L Rabin; A Ali; J T Barron |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Clinical cardiology Volume: 21 ISSN: 0160-9289 ISO Abbreviation: Clin Cardiol Publication Date: 1998 Feb |
Date Detail:
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Created Date: 1998-04-21 Completed Date: 1998-04-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7903272 Medline TA: Clin Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 100-2 Citation Subset: IM |
Affiliation:
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Department of Medicine, Rush Medical College, Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois 60612, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Dipyridamole / administration & dosage, adverse effects*, diagnostic use Electrocardiography Exercise Test / adverse effects, methods Female Humans Infusions, Intravenous Male Middle Aged Myocardial Ischemia / physiopathology, radionuclide imaging* Predictive Value of Tests Radiopharmaceuticals / diagnostic use Technetium Tc 99m Sestamibi / diagnostic use Thallium Radioisotopes / diagnostic use Vasodilator Agents / administration & dosage, adverse effects*, diagnostic use Ventricular Premature Complexes / chemically induced*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 0/Thallium Radioisotopes; 0/Vasodilator Agents; 109581-73-9/Technetium Tc 99m Sestamibi; 58-32-2/Dipyridamole |
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