| Association of vascular health and neurocognitive performance in overweight adults with high blood pressure. | |
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MedLine Citation:
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PMID: 21229433 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The relationship between vascular health-including flow-mediated dilation (FMD) and intima medial thickness (IMT)-and neurocognitive performance was examined in a sample of 124 sedentary, middle-aged adults with high blood pressure (systolic blood pressure, SBP, 130-159 mmHg or diastolic blood pressure, DBP, 85-99 mmHg) who were overweight or obese (body mass index 25.0-39.99 kg/m(2)). Patients completed a neuropsychological test battery, including measures of executive function and psychomotor speed, and measures of IMT and FMD were obtained. Hierarchical multiple regression analyses were used to investigate the association between vascular measures and neurocognitive performance after controlling for demographic factors and cerebrovascular risk factors. Higher levels of FMD predicted better executive function (b = 0.90, p = .045). Greater IMT tended to be associated with slower psychomotor speed (b = -0.82, p = .084), with the effect attenuated after controlling for FMD. Impaired FMD is associated with worse neurocognitive functioning among overweight adults with high blood pressure. |
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Authors:
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Patrick J Smith; James A Blumenthal; Michael A Babyak; Alan Hinderliter; Andrew Sherwood |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-10 |
Journal Detail:
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Title: Journal of clinical and experimental neuropsychology Volume: - ISSN: 1744-411X ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8502170 Medline TA: J Clin Exp Neuropsychol Country: - |
Other Details:
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Languages: ENG Pagination: 1-8 Citation Subset: - |
Affiliation:
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Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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