Document Detail

Association of umbilical placental vascular disease with fetal acute inflammatory cytokine responses.
MedLine Citation:
PMID:  12009389     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We examined the hypothesis that fetal proinflammatory cytokine release is a feature of placental vascular disease causing fetal compromise. We measured the concentrations of fetal proinflammatory cytokines interleukin 6 (IL-6), tumor necrosis factor alpha (TNF-alpha), and interleukin-8 (IL-8) in the presence of vascular disease in the umbilical placental villous circulation. Vascular disease was identified by high-resistance umbilical artery Doppler flow velocity waveform studies. METHODS: We measured levels of the inflammatory cytokines IL-6 and TNF-alpha and the chemokine IL-8 in fetal blood. Blood was collected from the umbilical vein at delivery, and serum was stored at -70C until assayed using chemiluminescent and enzyme-linked immunosorbent assay methods. We studied 36 normal pregnancies delivered by elective cesarean at term and 50 pregnancies with a high-resistance umbilical artery Doppler flow velocity waveform pattern indicative of fetal placental vascular disease delivered by elective cesarean because of potential fetal compromise. RESULTS: In the presence of umbilical placental vascular disease there were significantly higher levels of IL-6 (median 5.3 pg/mL, P <.05) and IL-8 (median 26.5 pg/mL, P <.01) compared with normal pregnancies (median value of IL-6 and IL-8 were below assay threshold). There was no difference for TNF-alpha, with the median results undetectable in both groups. CONCLUSION: We found higher concentrations of IL-6 and IL-8 in the fetal circulation in the presence of umbilical placental vascular disease.
Brian Trudinger; Jun Wang; Neil Athayde; Lucinda Beutler; Xin Wang
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the Society for Gynecologic Investigation     Volume:  9     ISSN:  1071-5576     ISO Abbreviation:  J. Soc. Gynecol. Investig.     Publication Date:    2002 May-Jun
Date Detail:
Created Date:  2002-05-15     Completed Date:  2002-09-16     Revised Date:  2010-03-23    
Medline Journal Info:
Nlm Unique ID:  9433806     Medline TA:  J Soc Gynecol Investig     Country:  United States    
Other Details:
Languages:  eng     Pagination:  152-7     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University of Sydney at Westmead Hospital, PO Box 533, Wentworthville, New South Wales 2145, Australia.
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MeSH Terms
Birth Weight
Cytokines / blood,  secretion*
Delivery, Obstetric
Fetal Blood / chemistry,  immunology
Fetal Diseases / physiopathology*
Gestational Age
Infant, Newborn
Inflammation / physiopathology*
Interleukin-6 / blood
Maternal Age
Placenta / blood supply*
Placental Insufficiency / physiopathology*
Reference Values
Tumor Necrosis Factor-alpha / analysis
Vascular Diseases / physiopathology*
Reg. No./Substance:
0/Cytokines; 0/Interleukin-6; 0/Tumor Necrosis Factor-alpha

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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