Document Detail

Association of two loci on chromosome 2q with nodal osteoarthritis.
MedLine Citation:
PMID:  8660106     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To search for genetic association between microsatellite marker loci and sibling pairs with nodal osteoarthritis (NOA). METHODS: Using the affected sibling pair method of analysis, genomic DNA from 66 sib pairs with NOA was analysed for association with highly polymorphic microsatellite marker loci. The microsatellite markers were amplified using polymerase chain reaction and typed on polyacrylamide gels. RESULTS: A significant association (p < 0.05) was identified between NOA and two loci on the short arm of chromosome 2 (2q 23-35). Candidate genes for osteoarthritis in this region include: fibronectin, a glycoprotein present in the extracellular matrix of normal cartilage; the alpha 2 chain of collagen type V, a major constituent of bone; and the interleukin-8 receptor, important in the regulation of neutrophil activation and chemotaxis. CONCLUSIONS: The chromosomal region 2q 23-35 requires further detailed study in NOA. Confirmation of these findings in large independent data sets and further analysis of candidate genes in this region will be important in unravelling the molecular basis for this common disease.
G D Wright; A E Hughes; M Regan; M Doherty
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  55     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-07-30     Completed Date:  1996-07-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  317-9     Citation Subset:  IM    
Department of Rheumatology, Musgrave Park Hospital, Belfast, United Kingdom.
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MeSH Terms
Aged, 80 and over
Chromosome Mapping
Chromosomes, Human, Pair 2 / genetics*
Genetic Markers
Microsatellite Repeats
Middle Aged
Osteoarthritis / genetics*
Reg. No./Substance:
0/Genetic Markers

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