Document Detail


Association of tumor necrosis factor α, interleukin 6, and interleukin 10 promoter polymorphism with proliferative diabetic retinopathy in type 2 diabetic subjects.
MedLine Citation:
PMID:  22105495     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: New blood vessel formation in the retina because of prolonged hypoxia is believed to be directly associated with increased expression of several growth factors and angiogenic cytokines. In the present study, we made an attempt to investigate the possible association of the promoter polymorphisms of interleukin 6, tumor necrosis factor α, and interleukin 10 for the pathogenesis of proliferative diabetic retinopathy (PDR).
METHODS: This case-control study comprised 493 volunteers (253 PDR cases and 240 diabetic controls). Cases and controls were ascertained such that age, sex, nutrition, and glycemic status were matched. Genotypes were determined by polymerase chain reaction-based methods.
RESULTS: Interleukin 10-1082GG (P = 0.0037; odds ratio [OR] = 2.232), tumor necrosis factor α-238AA (P = 0.0001; OR = 5.791), and GA (P = 0.0015; OR = 1.909) genotypes were significantly associated with PDR occurrence. The interleukin 10-1082G allele (P = 0.0048, OR = 1.4442) and the tumor necrosis factor α-238A allele (P = 0.0001; OR = 2.2897) were significantly increased among PDR cases.
CONCLUSION: From our study, it may be concluded that the genetic variation, that is, tumor necrosis factor α-238A and interleukin 10-1082G alleles are the potent risk factors for the pathogenesis of PDR.
Authors:
Suman K Paine; Aditi Sen; Subhadip Choudhuri; Lakshmi K Mondal; Imran H Chowdhury; Analabha Basu; Ankur Mukherjee; Basudev Bhattacharya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Retina (Philadelphia, Pa.)     Volume:  32     ISSN:  1539-2864     ISO Abbreviation:  Retina (Philadelphia, Pa.)     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-28     Completed Date:  2012-07-30     Revised Date:  2012-08-29    
Medline Journal Info:
Nlm Unique ID:  8309919     Medline TA:  Retina     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1197-203     Citation Subset:  IM    
Affiliation:
Department of Biochemistry, Dr BC Roy Post Graduate Institute of Basic Medical Education and Research, Kolkata, India.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Alleles
Case-Control Studies
Cross-Sectional Studies
Diabetes Mellitus, Type 2 / complications,  genetics
Diabetic Retinopathy / genetics*
Female
Humans
Interleukin-10 / genetics*
Interleukin-6 / genetics*
Male
Middle Aged
Polymerase Chain Reaction
Polymorphism, Single Nucleotide / genetics*
Promoter Regions, Genetic / genetics*
Tumor Necrosis Factor-alpha / genetics*
Chemical
Reg. No./Substance:
0/Interleukin-6; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10

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