| Association of total cholesterol versus other serum lipid parameters with the short-term prediction of cardiovascular outcomes: Tehran Lipid and Glucose Study. | |
| | |
MedLine Citation:
|
PMID: 16874147 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The aim of this study was to evaluate and compare the role of lipid markers including total, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol with lipid indices (total/HDL cholesterol, LDL-cholesterol/HDL-cholesterol and non-HDL-cholesterol) as predictors of cardiovascular outcomes in adults over 30 years. RESEARCH DESIGN AND METHOD: In a nested case-control study, 207 cardiovascular events among participants of the Tehran Lipid and Glucose Study (TLGS) were documented during 3 years of follow-up. Those cases that were free of cardiovascular disease at baseline (132 subjects) were matched to 264 controls for age and sex. In all subjects, demographic and clinical data including blood pressure and anthropometric measurements as well as serum lipids, fasting and 2-h plasma glucose were obtained from the database of the TLGS. We estimated the relative risk for each lipid parameter in a multiple stepwise regression model after adjustment for family history of premature coronary heart disease, smoking, systolic and diastolic blood pressure, fasting and 2-h plasma glucose and waist-to-hip ratio. RESULTS: The relative risks associated with an increase of approximately 1 SD of independent lipid predictors in the multivariate model were as follows: total cholesterol, 1.6 (1.2-2.1), SD=1.3 mmol/l; LDL-cholesterol 1.5 (1.1-2.0), SD=1 mmol/l; non-HDL-cholesterol 1.6 (1.2-2.1), SD=1.2 mmol/l and cholesterol/HDL-cholesterol 1.5 (1.1-2.0), SD=1.8. Comparison of these four independent variables with receiver-operating characteristic curve analysis showed no significant difference in their predictive power for cardiovascular outcome. There was no association between HDL-cholesterol, triglyceride and LDL/HDL cholesterol and cardiovascular disease outcomes in multivariate analysis. CONCLUSION: It seems that for short-term prediction of cardiovascular disease outcome, serum total cholesterol is the preferred lipid parameter to measure in the Iranian population. |
| | |
Authors:
|
Farzad Hadaegh; Hadi Harati; Arash Ghanbarian; Fereidoun Azizi |
Related Documents
:
|
8155487 - New data about the effects of oral physiological magnesium supplementation on several c... 3239107 - Changes of some lipid and lipid peroxidation characteristics in obese people as a resul... 8677757 - Prognostic relevance of lipoprotein cholesterol levels in acute lymphocytic and nonlymp... 11487447 - New developments in the prevention of atherosclerosis in patients with low high-density... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of cardiovascular prevention and rehabilitation : official journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology Volume: 13 ISSN: 1741-8267 ISO Abbreviation: Eur J Cardiovasc Prev Rehabil Publication Date: 2006 Aug |
Date Detail:
|
Created Date: 2006-07-28 Completed Date: 2006-12-07 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101192000 Medline TA: Eur J Cardiovasc Prev Rehabil Country: England |
Other Details:
|
Languages: eng Pagination: 571-7 Citation Subset: IM |
Affiliation:
|
Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Aged, 80 and over Biological Markers / blood Blood Glucose / metabolism* Cardiovascular Diseases / blood*, epidemiology Cholesterol, HDL / blood* Cholesterol, LDL / blood* Female Follow-Up Studies Humans Iran / epidemiology Male Middle Aged Prevalence Prognosis Retrospective Studies Risk Factors Urban Population* |
| Chemical | |
Reg. No./Substance:
|
0/Biological Markers; 0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Favorable cardiovascular risk profile and 10-year coronary heart disease incidence in women and men:...
Next Document: Does cumulating endurance training at the weekends impair training effectiveness?