Document Detail

Association of systemic risk factors with the progression of laser-treated retinopathy of prematurity to retinal detachment.
MedLine Citation:
PMID:  18317347     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To identify systemic risk factors associated with treatment failure of diode laser photocoagulation for threshold or prethreshold retinopathy of prematurity (ROP). METHODS: Consecutive infants treated with laser at our institution and infants referred from outside centers with progression to stage 4 or 5 ROP after laser treatment were included in this retrospective study. Two groups were identified: those with regression of ROP after laser (LT group; 196 eyes of 98 infants) and those with progression to stage 4 or 5 ROP after laser (ST group; 134 eyes of 80 infants). RESULTS: Using a multiple logistic regression model, there was a statistically significant association for progression of treated ROP to retinal detachment (RD) with history of sepsis (P < 0.001), oxygen therapy (P = 0.003), mechanical ventilation (P = 0.003), respiratory distress syndrome (RDS; P = 0.005), and patent ductus arteriosus (PDA; P = 0.042). On the other hand, jaundice (P = 0.563), anemia (P = 0.599), thrombocytopenia (P = 0.689), and blood transfusion (P = 0.878) did not show a statistically significant association with failure of laser treatment and progression of ROP to stage 4 or 5 disease. CONCLUSIONS: Premature infants with a history sepsis, oxygen therapy, mechanical ventilation, RDS, and PDA may be at a higher risk for progression of ROP despite diode laser treatment.
Dan H Bourla; Christine R Gonzales; Sevak Valijan; Fei Yu; Charles W Mango; Steven D Schwartz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Retina (Philadelphia, Pa.)     Volume:  28     ISSN:  0275-004X     ISO Abbreviation:  Retina (Philadelphia, Pa.)     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-03-10     Completed Date:  2008-04-29     Revised Date:  2009-02-10    
Medline Journal Info:
Nlm Unique ID:  8309919     Medline TA:  Retina     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S58-64     Citation Subset:  IM    
Jules Stein Eye Institute, Los Angeles, California, USA.
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MeSH Terms
Disease Progression
Infant, Newborn
Laser Therapy*
Retinal Detachment / etiology*
Retinopathy of Prematurity / complications*,  surgery*
Retrospective Studies
Risk Factors
Treatment Failure
Erratum In:
Retina. 2009 Jan;29(1):127

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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