Document Detail

Association of systemic inflammatory activity with coronary and carotid atherosclerosis in the very elderly.
MedLine Citation:
PMID:  21316055     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To verify the existence of association between plasma levels of pro- or anti-inflammatory mediators and atherosclerotic burden at coronary and carotid arteries in individuals aged of 80 or more years old. METHODS: Healthy individuals aged between 80 and 102 years old (n=178) underwent evaluation of plasma cytokines and acute phase proteins, intima-media thickness (IMT) and presence of plaques in carotid arteries by ultrasound and coronary artery calcification (CAC) by cardiac computed tomography. RESULTS: There was no association between CAC and carotid plaques (p=0.8), maximum (p=0.06) or mean IMT (p=0.2). No association was found between the presence of carotid plaques and CRP (p=0.4), TNF-α (p=0.8) or IL-10 (p=0.2). Likewise, individuals in the first three quartiles for CRP, TNF-α or IL-10 had similar values of CAC, mean and maximum IMT. In contrast, individuals above the 75th percentile for CRP or for TNF-α had enhanced maximum IMT (p=0.017 and p<0.0001) and CAC (p=0.026 and p=0.01) and subjects with IL-10 levels above the 75th percentile had lower maximum IMT (p=0.027) and CAC (p=0.006) as compared with those below this percentile. There was no difference in mean IMT for individuals above or below the 75th percentile for CRP, TNF-α or IL-10. CONCLUSION: In very old individuals, CAC and maximum IMT were positively associated with systemic inflammatory activity only in those above the 75th percentile. The markers of atherosclerotic burden at coronary and carotid arteries were not related to each other and were distinctly associated with pro- and anti-inflammatory mediators, suggesting that atherosclerosis development is different in these vascular beds.
Wladimir M Freitas; Luiz A Quaglia; Simone N Santos; Alexandre A S Soares; André V T Japiassú; Vinicius Boaventura; Edilberto Dos Santos Barros; Cláudio Córdova; Otávio T Nóbrega; Andrei C Sposito
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-2
Journal Detail:
Title:  Atherosclerosis     Volume:  -     ISSN:  1879-1484     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-2-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.
University of Brasilia Medical School (UnB), Brasília, DF, Brazil; Instituto de Cardiologia Biocardios, Brasília, DF, Brazil.
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