Document Detail

Association study of interleukin-12A gene polymorphisms with Graves' disease in two Chinese populations.
MedLine Citation:
PMID:  21044109     Owner:  NLM     Status:  In-Process    
OBJECTIVE: Graves' disease (GD) is a common autoimmune disorder and genetic and environmental factors contributing to its aetiology. The pro-inflammatory cytokine interleukin-12 (IL-12) is believed to be critically involved in the pathogenesis of GD. This study aims to elucidate the effect of IL-12A gene polymorphisms on GD.
DESIGN AND METHODS: A case-control association study of five tag single nucleotide polymorphisms (SNPs) (rs2243115, rs2243123, rs583911, rs568408 and rs2243143) within the IL-12A gene was performed in two independent Chinese cohorts. A pilot cohort conducted in Shanghai consisted of 701 patients and 686 controls and a replicate cohort in Xiamen Island included 378 patients and 312 controls. The five SNPs were genotyped by the SNPstream Genotyping Systems and Taqman PCR method.
RESULTS: Polymorphism of rs568408, located at the 3'-UTR region, was found to have a significant association with GD in both the cohorts (P(allele) = 2·96 × 10⁻⁷ and P(allele) = 0·013 for Shanghai and Xiamen Island cohorts, respectively). Haplotype analysis showed that the haplotype of the five SNPs (TTAAG) was associated with a significant risk of GD in both the cohorts (OR = 2·04 and OR = 1·70 for Shanghai and Xiamen Island cohorts, respectively).
CONCLUSION: Our results have established an association between IL-12A polymorphism and GD susceptibility in the Chinese population.
Ting Guo; Shuyu Yang; Nan Liu; Shu Wang; Bin Cui; Guang Ning
Related Documents :
16858129 - Three novel single nucleotide polymorphisms of the fmo3 gene in a japanese population.
20018059 - Evaluation of single-nucleotide polymorphism imputation using random forests.
17366619 - Genetic variation of antigen processing machinery components and association with cervi...
17463019 - Snp detection exploiting multiple sources of redundancy in large est collections improv...
19956539 - How many genetic variants remain to be discovered?
19356949 - Cytokine snps: comparison of allele frequencies by race and implications for future stu...
9048929 - A high-frequency polymorphism of nadh-cytochrome b5 reductase in african-americans.
1937479 - Analysis of 14 cystic fibrosis mutations in five south european populations.
23064449 - Two genotypes among 'candidatus mycoplasma haemobos' strains based on the 16s-23s rrna ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical endocrinology     Volume:  74     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  England    
Other Details:
Languages:  eng     Pagination:  125-9     Citation Subset:  IM    
Copyright Information:
© 2010 Blackwell Publishing Ltd.
Shanghai Institutes for Biological Sciences, Shanghai JiaoTong University School of Medicine, China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  An alternative impression technique for individuals with special care needs.
Next Document:  Effects of pulse methylprednisolone and oral methylprednisolone treatments on serum levels of oxidat...