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Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk, diabetic nephropathy in the Chinese She population.
MedLine Citation:
PMID:  23298195     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Genetic determinations are important in type 2 diabetes (T2D) pathology. We investigated associations between genetic variants of 17 diabetes-related genes/loci, T2D and diabetic complications in Chinese She subjects. METHODS: A comprehensive gene-based association study was conducted using 17 single nucleotide polymorphisms (SNPs) in Chinese She subjects with normal glucose tolerance (NGT; n=1119), impaired glucose regulation (IGR; n=1767), and T2D (n=443). We applied major abnormal Minnesota Code findings to predict cardiovascular risk and estimated glomerular filtration rate (eGFR) to assess kidney function. RESULTS: Nine variants in FTO rs8050136, WFS1 rs10010131, CDKN2A/B rs10811661, KCNJ11 rs5219, CDC123/CAMK1D rs12779790, JAZF1 rs864745, SLC30A8 rs13266634, CDKAL1 rs10946398 and HHEX/IDE rs5015480 were significantly associated with T2D (p<0.05). SNPs in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMK1D rs12779790, JAZF1 rs864745, FTO rs8050136 and HHEX/IDE rs5015480 were associated with T2D and IGR. Risk alleles in WFS1 rs10010131, IGF2BP2 rs4402960, CDKAL1 rs10946398, FTO rs8050136, KCNQ1 rs2237897 and ADAMTS9 rs4607103 were significantly associated with decreased HOMA-β (p<0.05). After adjusting for age, gender and BMI, genetic variants JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were significantly related to reduced eGFR (p<0.05). Genetic variants in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMID rs12779790, JAZF1 rs864745, FTO rs80501360, CDKAL1 rs10946398 and HHEX/IDE rs5015480 correlated with abnormal major Minnesota Code findings (p<0.05). CONCLUSION: Variants in WFS1, CDKN2A/B, KCNJ11, CDC123/CAMK1D, JAZF1, SLC30A8, FTO, CDKAL1 and HHEX/IDE genes are significantly associated with T2D in She Chinese subjects. JAZF1, FTO, CDKAL1 and HHEX/IDE are associated with diabetic nephropathy. WFS1, CDKN2A/B, CDC123/CAMK1D, JAZF1, FTO, CDKAL1 and HHEX/IDE are associated with cardiovascular risk. © 2013 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
Authors:
Gang Chen; Yuan Xu; Yinghua Lin; Xiaolan Lai; Jin Yao; Baoying Huang; Zichun Chen; Huibin Huang; Xianguo Fu; Lixiang Lin; Shenghan Lai; Junping Wen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Journal of diabetes     Volume:  -     ISSN:  1753-0407     ISO Abbreviation:  J Diabetes     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101504326     Medline TA:  J Diabetes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
Affiliation:
Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fuzhou, 350001, China.
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