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Association study of genetic variants of 17 diabetes-related genes/loci and cardiovascular risk, diabetic nephropathy in the Chinese She population.
MedLine Citation:
PMID:  23298195     Owner:  NLM     Status:  Publisher    
BACKGROUND: Genetic determinations are important in type 2 diabetes (T2D) pathology. We investigated associations between genetic variants of 17 diabetes-related genes/loci, T2D and diabetic complications in Chinese She subjects. METHODS: A comprehensive gene-based association study was conducted using 17 single nucleotide polymorphisms (SNPs) in Chinese She subjects with normal glucose tolerance (NGT; n=1119), impaired glucose regulation (IGR; n=1767), and T2D (n=443). We applied major abnormal Minnesota Code findings to predict cardiovascular risk and estimated glomerular filtration rate (eGFR) to assess kidney function. RESULTS: Nine variants in FTO rs8050136, WFS1 rs10010131, CDKN2A/B rs10811661, KCNJ11 rs5219, CDC123/CAMK1D rs12779790, JAZF1 rs864745, SLC30A8 rs13266634, CDKAL1 rs10946398 and HHEX/IDE rs5015480 were significantly associated with T2D (p<0.05). SNPs in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMK1D rs12779790, JAZF1 rs864745, FTO rs8050136 and HHEX/IDE rs5015480 were associated with T2D and IGR. Risk alleles in WFS1 rs10010131, IGF2BP2 rs4402960, CDKAL1 rs10946398, FTO rs8050136, KCNQ1 rs2237897 and ADAMTS9 rs4607103 were significantly associated with decreased HOMA-β (p<0.05). After adjusting for age, gender and BMI, genetic variants JAZF1 rs864745, FTO rs8050136, and HHEX/IDE rs5015480 were significantly related to reduced eGFR (p<0.05). Genetic variants in WFS1 rs10010131, CDKN2A/B rs10811661, CDC123/CAMID rs12779790, JAZF1 rs864745, FTO rs80501360, CDKAL1 rs10946398 and HHEX/IDE rs5015480 correlated with abnormal major Minnesota Code findings (p<0.05). CONCLUSION: Variants in WFS1, CDKN2A/B, KCNJ11, CDC123/CAMK1D, JAZF1, SLC30A8, FTO, CDKAL1 and HHEX/IDE genes are significantly associated with T2D in She Chinese subjects. JAZF1, FTO, CDKAL1 and HHEX/IDE are associated with diabetic nephropathy. WFS1, CDKN2A/B, CDC123/CAMK1D, JAZF1, FTO, CDKAL1 and HHEX/IDE are associated with cardiovascular risk. © 2013 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
Gang Chen; Yuan Xu; Yinghua Lin; Xiaolan Lai; Jin Yao; Baoying Huang; Zichun Chen; Huibin Huang; Xianguo Fu; Lixiang Lin; Shenghan Lai; Junping Wen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-9
Journal Detail:
Title:  Journal of diabetes     Volume:  -     ISSN:  1753-0407     ISO Abbreviation:  J Diabetes     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101504326     Medline TA:  J Diabetes     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.
Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fujian Provincial Hospital Key Laboratory of Endocrinology, Fuzhou, 350001, China.
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