Document Detail

Association study between cannabinoid receptor gene (CNR1) and pathogenesis and psychotic symptoms of mood disorders.
MedLine Citation:
PMID:  11353438     Owner:  NLM     Status:  MEDLINE    
Cannabis can induce mood change and sometimes psychotic symptoms in normal persons. In brain, the main active ingredient of cannabis acts via the cannabinoid CB1 receptor (CNR1) which is located on chromosome 6q14-15. Linkage studies have suggested the presence of a bipolar disorder susceptibility locus on chromosome 6q. In this population based association study, we tested the hypothesis that a microsatellite polymorphism in the promoter region of the CNR1 gene confers susceptibility to mood disorders and psychotic features. We genotyped the CNR1 gene is 154 mood disorder patients and 165 normal controls. The results showed that the triplet repeat polymorphism in the promoter region of the CNR1 gene was not likely to be involved in the pathogenesis or in the psychotic symptoms of mood disorders.
S J Tsai; Y C Wang; C J Hong
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of medical genetics     Volume:  105     ISSN:  0148-7299     ISO Abbreviation:  Am. J. Med. Genet.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-05-15     Completed Date:  2001-12-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7708900     Medline TA:  Am J Med Genet     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-21     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Wiley-Liss, Inc.
Department of Psychiatry, Veterans General Hospital-Taipei, Taipei, Taiwan ROC.
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MeSH Terms
Affective Disorders, Psychotic / etiology,  genetics
Asian Continental Ancestry Group / genetics
Case-Control Studies
Gene Frequency
Genetic Predisposition to Disease
Genetic Variation
Microsatellite Repeats
Middle Aged
Mood Disorders / etiology*,  genetics
Polymorphism, Genetic
Promoter Regions, Genetic
Receptors, Cannabinoid
Receptors, Drug / genetics*
Trinucleotide Repeats
Reg. No./Substance:
0/Receptors, Cannabinoid; 0/Receptors, Drug

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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