Document Detail


Association study of a (TG)n dinucleotide repeat at chromosome 15q13.3 and schizophrenia in the Chinese population.
MedLine Citation:
PMID:  18346794     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Linkage studies have suggested that chromosome 15q13-q14 may harbor a susceptibility locus for schizophrenia. In the current study, the association between a (TG)n dinucleotide repeat polymorphism at D15S976 and schizophrenia was investigated using two independent samples from the Han Chinese population. In a population-based study, no significant difference was found between the genotype and allele frequency distributions in schizophrenia patients and control subjects. In a family-based study, no significant transmission disequilibrium from heterozygous parents to affected offspring was observed. Further analysis of the parent-of-origin effect found nominally significant allele-wise transmission disequilibrium through maternal transmissions, while 157bp and 159bp alleles showed significant individual allelic transmission disequilibrium from heterozygous mothers to affected offspring. Our results did not support the hypothesis that the (TG)n dinucleotide repeat polymorphism plays a major role in schizophrenia susceptibility in the Chinese population. Further studies are needed to elucidate the putative parent-of-origin effect and its role in schizophrenia susceptibility.
Authors:
Jie Ma; Jin-Bo Fan; Li Bian; Chang-Shun Zhang; Xing-Wang Li; Niu-Fan Gu; Guo-Yin Feng; David St Clair; Lin He
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-03-17
Journal Detail:
Title:  Psychiatry research     Volume:  159     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-05-05     Completed Date:  2008-07-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  245-9     Citation Subset:  IM    
Affiliation:
Bio-X Center, Shanghai Jiao Tong University, Shanghai, 200030, PR China.
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MeSH Terms
Descriptor/Qualifier:
Adult
Asian Continental Ancestry Group / genetics*
China / epidemiology
Chromosome Mapping
Chromosomes, Human, Pair 15 / genetics*
Dinucleotide Repeats / genetics*
Family
Female
Gene Frequency
Genetic Heterogeneity
Genetic Predisposition to Disease / genetics
Genotype
Haplotypes / genetics
Humans
Linkage Disequilibrium / genetics
Male
Polymorphism, Genetic
Schizophrenia / epidemiology,  genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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