Document Detail


Association of the single nucleotide polymorphism rs599839 in the vicinity of the sortilin 1 gene with LDL and triglyceride metabolism, coronary heart disease and myocardial infarction. The Ludwigshafen Risk and Cardiovascular Health Study.
MedLine Citation:
PMID:  19837406     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The rs599839 polymorphism A/G in the vicinity of the sortilin 1 gene has been reported to be associated with low density lipoprotein cholesterol (LDL-C) and coronary artery disease (CAD). The objective of this study was to further characterize the protective effect of the minor allele by analyzing the association with a variety of quantitative traits. METHODS: Association of rs599839 with plasma levels of different parameters of LDL and triglyceride (TRIG) metabolism as well as the risk of CAD was tested in the LURIC study cohort. RESULTS: Compared to AA homozygotes, the levels of LDL-C, low density lipoprotein triglycerides (LDL-TRIG) and apolipoprotein B were decreased in carriers of at least one G-allele. The G-allele was also associated with an increasing radius of the LDL particles. Regarding TRIG metabolism we observed a significant decrease in the level of triglycerides for homozygous carriers of the G-allele as well as decreased levels of free fatty acids (FFA), free glycerol and free cholesterol. With each G-allele the prevalence of CAD (multivariate OR 0.806; 95% CI: 0.692-0.940, P=0.006) decreased significantly whereas we observed only a marginal decrease for MI which did not reach significance. For GG homozygotes, the OR for CAD was 0.588 (95% CI: 0.394-0.877; P=0.009) and the OR for previous myocardial infarction (MI) was 0.693 (95% CI: 0.490-0.980; P=0.038). These associations were independent of cardiovascular risk factors. CONCLUSION: In the LURIC Study the G-allele of rs599839 is associated with LDL and TRIG metabolism and the risk of coronary artery disease and myocardial infarction.
Authors:
Marcus E Kleber; Wilfried Renner; Tanja B Grammer; Patrick Linsel-Nitschke; Bernhard O Boehm; Bernhard R Winkelmann; Peter Bugert; Michael M Hoffmann; Winfried M?rz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-02
Journal Detail:
Title:  Atherosclerosis     Volume:  209     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-03-26     Completed Date:  2010-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  492-7     Citation Subset:  IM    
Copyright Information:
Copyright 2009 Elsevier Ireland Ltd. All rights reserved.
Affiliation:
LURIC Study Nonprofit LLC, Freiburg, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adaptor Proteins, Vesicular Transport / genetics*
Adolescent
Adult
Aged
Cholesterol, LDL / blood*
Chromosomes, Human, Pair 1 / genetics*
Coronary Disease / blood,  genetics
Female
Humans
Lipoproteins, LDL / blood*
Male
Middle Aged
Myocardial Infarction / genetics*
Polymorphism, Single Nucleotide*
Triglycerides / blood*
Chemical
Reg. No./Substance:
0/Adaptor Proteins, Vesicular Transport; 0/Cholesterol, LDL; 0/Lipoproteins, LDL; 0/Triglycerides; 0/low density lipoprotein triglyceride; 0/sortilin

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