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Association of shorter mean telomere length with large artery stiffness in patients with coronary heart disease.
MedLine Citation:
PMID:  21067315     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background.?Accumulating evidence implicates leukocyte telomere length (LTL) shortening as a potential risk predictor for cardiovascular disease. Arterial stiffness chronicles the cumulative burden of cardiovascular disease risk factors. Therefore, the capacity of LTL to predict arterial stiffness was examined. Methods.?A total of 275 unrelated Chinese males: 163 patients with coronary artery disease (CAD) and 112 healthy controls, 40?73 years of age were included in this study. The relative telomere length of leukocytes was determined by a real-time fluorescence quantitative polymerase chain reaction (PCR). Large artery stiffness was measured with carotid-femoral pulse wave velocity (PWV). Results.?The relative telomere length (T/S) ratio was significantly shorter in patients with CAD (0.79???0.26) than in control subjects (1.08???0.22) (p?<?0.001). The correlation between LTL and PWV in patients with CAD was stronger than that in the controls (r?=??0.467, r(2)?=?0.227, p?<?0.001 for patients with CAD versus r?=??0.223; r (2)?=?0.050; p?=?0.018 for controls). The log(e)-transformed T/S ratio was inversely correlated with age (r?=??0.345; p?<?0.001), PWV (r?=??0.326; p?<?0.001) and C-reactive protein ( r?=??0.133; p?=?0.027). Conclusions.?The data show an association of leukocyte telomere length shortening with increased arterial stiffness and cardiovascular burden, suggesting that telomere length is a biomarker of large artery elasticity and CAD. Further studies are warranted to study the role of LTL dynamics in the pathogenesis of atherosclerosis.
Authors:
Yun-Ying Wang; Ai-Fang Chen; Hua-Zhang Wang; Li-Yan Xie; Ke-Xu Sui; Qi-Yi Zhang
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Publication Detail:
Type:  Journal Article     Date:  2010-11-10
Journal Detail:
Title:  The aging male : the official journal of the International Society for the Study of the Aging Male     Volume:  14     ISSN:  1473-0790     ISO Abbreviation:  Aging Male     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9808210     Medline TA:  Aging Male     Country:  England    
Other Details:
Languages:  eng     Pagination:  27-32     Citation Subset:  IM    
Affiliation:
Department of Medical Genetics, Affiliated Qingdao Municipal Hospital of Qingdao University Medical College, Qingdao, Shandong, 266011, PR China.
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