Document Detail

Association of shorter mean telomere length with risk of incident myocardial infarction: a prospective, nested case-control approach.
MedLine Citation:
PMID:  19217888     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recent data have implicated telomere length shortening as a potential risk predictor for cardiovascular disease. However, to date, prospective epidemiological data are scarce.
METHODS: Using leukocyte DNA samples collected at baseline in a prospective cohort of 14,916 initially healthy American men, we examined the relationship of mean telomere repeat copy number to single gene copy number (T/S ratio), using a re-modified quantitative polymerase chain reaction protocol, among 337 white males who subsequently developed an incident myocardial infarction (MI), and among an equal number of age- and smoking-matched white males who remained free of reported vascular disease during follow-up (controls).
RESULTS: The mean follow-up time since randomization was 3.85 y. The T/S ratio was inversely correlated with age in the controls (R=-0.114; p=0.036). The log(e)-transformed T/S ratios were significantly smaller in the MI cases (3.41+/-0.63) than the MI controls (3.52+/-0.78) (p=0.01). In a multi-variable adjusted analysis, decreased T/S ratio was significantly associated with risk of MI (odds ratio=1.621; 95%CI=1.140-2.304; p=0.007).
CONCLUSIONS: The present investigation has shown an association of telomere length shortening with increased risk of incident myocardial infarction, further suggesting the importance of telomere biology in atherogenesis.
Robert Y L Zee; Sherri E Michaud; Soren Germer; Paul M Ridker
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-02-13
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  403     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-27     Completed Date:  2009-07-06     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  139-41     Citation Subset:  IM    
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MeSH Terms
Aged, 80 and over
Case-Control Studies
Disease Susceptibility*
Follow-Up Studies
Logistic Models
Middle Aged
Myocardial Infarction / genetics*
Polymerase Chain Reaction
Prospective Studies
Randomized Controlled Trials as Topic
Telomere / genetics*
Grant Support
HL-58755/HL/NHLBI NIH HHS; HL-63293/HL/NHLBI NIH HHS; R01 HL058755-02/HL/NHLBI NIH HHS; R01 HL058755-03/HL/NHLBI NIH HHS; R01 HL063293/HL/NHLBI NIH HHS; R01 HL063293-01/HL/NHLBI NIH HHS; R01 HL063293-02/HL/NHLBI NIH HHS; R01 HL063293-03/HL/NHLBI NIH HHS; R01 HL063293-04/HL/NHLBI NIH HHS

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