| Association of shorter mean telomere length with risk of incident myocardial infarction: a prospective, nested case-control approach. | |
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MedLine Citation:
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PMID: 19217888 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Recent data have implicated telomere length shortening as a potential risk predictor for cardiovascular disease. However, to date, prospective epidemiological data are scarce. METHODS: Using leukocyte DNA samples collected at baseline in a prospective cohort of 14,916 initially healthy American men, we examined the relationship of mean telomere repeat copy number to single gene copy number (T/S ratio), using a re-modified quantitative polymerase chain reaction protocol, among 337 white males who subsequently developed an incident myocardial infarction (MI), and among an equal number of age- and smoking-matched white males who remained free of reported vascular disease during follow-up (controls). RESULTS: The mean follow-up time since randomization was 3.85 y. The T/S ratio was inversely correlated with age in the controls (R=-0.114; p=0.036). The log(e)-transformed T/S ratios were significantly smaller in the MI cases (3.41+/-0.63) than the MI controls (3.52+/-0.78) (p=0.01). In a multi-variable adjusted analysis, decreased T/S ratio was significantly associated with risk of MI (odds ratio=1.621; 95%CI=1.140-2.304; p=0.007). CONCLUSIONS: The present investigation has shown an association of telomere length shortening with increased risk of incident myocardial infarction, further suggesting the importance of telomere biology in atherogenesis. |
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Authors:
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Robert Y L Zee; Sherri E Michaud; Soren Germer; Paul M Ridker |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2009-02-13 |
Journal Detail:
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Title: Clinica chimica acta; international journal of clinical chemistry Volume: 403 ISSN: 1873-3492 ISO Abbreviation: Clin. Chim. Acta Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-04-27 Completed Date: 2009-07-06 Revised Date: 2010-09-22 |
Medline Journal Info:
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Nlm Unique ID: 1302422 Medline TA: Clin Chim Acta Country: Netherlands |
Other Details:
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Languages: eng Pagination: 139-41 Citation Subset: IM |
Affiliation:
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Center for Cardiovascular Disease Prevention, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. rzee@rics.bwh.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Case-Control Studies Disease Susceptibility* Follow-Up Studies Humans Logistic Models Male Middle Aged Myocardial Infarction / genetics* Polymerase Chain Reaction Prospective Studies Randomized Controlled Trials as Topic Telomere / genetics* |
| Grant Support | |
ID/Acronym/Agency:
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HL-58755/HL/NHLBI NIH HHS; HL-63293/HL/NHLBI NIH HHS; R01 HL058755-02/HL/NHLBI NIH HHS; R01 HL058755-03/HL/NHLBI NIH HHS; R01 HL063293-01/HL/NHLBI NIH HHS; R01 HL063293-02/HL/NHLBI NIH HHS; R01 HL063293-03/HL/NHLBI NIH HHS; R01 HL063293-04/HL/NHLBI NIH HHS |
| Comments/Corrections | |
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