Document Detail


Association of serum uric acid level with non-alcoholic fatty liver disease: a cross-sectional study.
MedLine Citation:
PMID:  19299029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIM: Serum uric acid level has been suggested to be associated with factors that contribute to the metabolic syndrome. The aim of this study was to investigate the association of serum uric acid level with non-alcoholic fatty liver disease (NAFLD).
METHODS: A cross-sectional study was performed among the employees of Zhenhai Refining & Chemical Company Ltd., Ningbo, China.
RESULTS: The study included 8925 subjects (6008 men) with a mean age of 43 years. The prevalence rates of NAFLD and hyperuricemia were 11.78% and 14.71%, respectively. NAFLD patients had significantly higher serum uric acid levels than controls (370.3+/-86.6 vs. 321.1+/-82.6 micromol/L; P<0.001). The prevalence rate of NAFLD was significantly higher in subjects with hyperuricemia than in those without hyperuricemia (24.75% vs. 9.54%; P<0.001), and the prevalence rate increased with progressively higher serum uric acid levels (P value for trend <0.001). Multiple regression analysis showed that hyperuricemia was associated with an increased risk of NAFLD (odds ratio [OR]: 1.291, 95% confidence interval [CI]: 1.067-1.564; P<0.001).
CONCLUSION: Serum uric acid level is significantly associated with NAFLD, and elevated serum uric acid level is an independent risk factor for NAFLD.
Authors:
Youming Li; Chengfu Xu; Chaohui Yu; Lei Xu; Min Miao
Related Documents :
15076279 - The use of chemical treatments for improved comminution of artificial stones.
10596359 - Formulation development of allopurinol suppositories and injectables.
20035639 - Uric acid is not an independent predictor of cardiovascular death in patients with angi...
3486509 - Prevalence of canine uroliths. minnesota urolith center.
5635159 - Anhydrous uric acid: nature and occurrence of a new form of urinary calculi.
550699 - Amniotic fluid creatinine and uric acid levels in high risk pregnancy.
17659779 - Isolation and molecular cloning of a fish myeloperoxidase.
22499199 - Isotope effects associated with the preparation and methylation of fatty acids by boron...
21212559 - Tigloylshikonin, a new minor shikonin derivative, from the roots and the commercial roo...
Publication Detail:
Type:  Journal Article     Date:  2009-01-09
Journal Detail:
Title:  Journal of hepatology     Volume:  50     ISSN:  1600-0641     ISO Abbreviation:  J. Hepatol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-22     Completed Date:  2009-08-17     Revised Date:  2012-08-24    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1029-34     Citation Subset:  IM    
Affiliation:
Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, PR China. xiaofu@zju.edu.cn
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Biological Markers / blood
China / epidemiology
Cross-Sectional Studies
Fatty Liver / blood*,  epidemiology*,  ethnology
Female
Humans
Male
Metabolic Syndrome X / blood,  epidemiology,  ethnology
Middle Aged
Prevalence
Regression Analysis
Risk Factors
Uric Acid / blood*
Chemical
Reg. No./Substance:
0/Biological Markers; 69-93-2/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Serial imaging changes during treatment of Takayasu arteritis with pulmonary artery stenosis.
Next Document:  Differences in general practice initiated expenditures across Danish local health authorities-A mult...