Document Detail

Association of serum uric acid level with non-alcoholic fatty liver disease: a cross-sectional study.
MedLine Citation:
PMID:  19299029     Owner:  NLM     Status:  MEDLINE    
BACKGROUND/AIM: Serum uric acid level has been suggested to be associated with factors that contribute to the metabolic syndrome. The aim of this study was to investigate the association of serum uric acid level with non-alcoholic fatty liver disease (NAFLD).
METHODS: A cross-sectional study was performed among the employees of Zhenhai Refining & Chemical Company Ltd., Ningbo, China.
RESULTS: The study included 8925 subjects (6008 men) with a mean age of 43 years. The prevalence rates of NAFLD and hyperuricemia were 11.78% and 14.71%, respectively. NAFLD patients had significantly higher serum uric acid levels than controls (370.3+/-86.6 vs. 321.1+/-82.6 micromol/L; P<0.001). The prevalence rate of NAFLD was significantly higher in subjects with hyperuricemia than in those without hyperuricemia (24.75% vs. 9.54%; P<0.001), and the prevalence rate increased with progressively higher serum uric acid levels (P value for trend <0.001). Multiple regression analysis showed that hyperuricemia was associated with an increased risk of NAFLD (odds ratio [OR]: 1.291, 95% confidence interval [CI]: 1.067-1.564; P<0.001).
CONCLUSION: Serum uric acid level is significantly associated with NAFLD, and elevated serum uric acid level is an independent risk factor for NAFLD.
Youming Li; Chengfu Xu; Chaohui Yu; Lei Xu; Min Miao
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Publication Detail:
Type:  Journal Article     Date:  2009-01-09
Journal Detail:
Title:  Journal of hepatology     Volume:  50     ISSN:  1600-0641     ISO Abbreviation:  J. Hepatol.     Publication Date:  2009 May 
Date Detail:
Created Date:  2009-04-22     Completed Date:  2009-08-17     Revised Date:  2012-08-24    
Medline Journal Info:
Nlm Unique ID:  8503886     Medline TA:  J Hepatol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1029-34     Citation Subset:  IM    
Department of Gastroenterology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, PR China.
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MeSH Terms
Biological Markers / blood
China / epidemiology
Cross-Sectional Studies
Fatty Liver / blood*,  epidemiology*,  ethnology
Metabolic Syndrome X / blood,  epidemiology,  ethnology
Middle Aged
Regression Analysis
Risk Factors
Uric Acid / blood*
Reg. No./Substance:
0/Biological Markers; 69-93-2/Uric Acid

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