Document Detail


Association of serum n-6 and n-3 polyunsaturated fatty acids with lipids in 3 populations of middle-aged men.
MedLine Citation:
PMID:  19474136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The association of serum polyunsaturated fatty acids (PUFAs) with lipids in different populations is not known.
OBJECTIVE: Our aim was to examine the association of serum n-6 (omega-6) or n-3 (omega-3) PUFAs with triglycerides or HDL-cholesterol concentrations in 261 white, 285 Japanese, and 212 Japanese American men aged 40-49 y.
DESIGN: We used a population-based cross-sectional study. Of the original sample (n = 926), those taking lipid-lowering medications or who had diabetes (n = 168) were excluded. Serum fatty acids were analyzed by capillary gas-liquid chromatography. Multiple regression models as a function of tertile groups of each PUFA were used.
RESULTS: Serum n-6 PUFAs were significantly inversely associated with triglycerides across populations after adjustment for age, body mass index, pack-years of smoking, and ethanol consumption [beta = -0.39 (P < 0.001), -0.38 (P < 0.001), and -0.33 (P < 0.001) in whites, Japanese, and Japanese Americans, respectively]. Marine n-3 PUFAs were significantly inversely associated with triglycerides across populations [beta = -0.15 (P < 0.001), -0.22 (P < 0.001), and -0.13 (P < 0.001) in whites, Japanese, and Japanese Americans, respectively]. n-6 PUFAs were significantly positively associated with HDL cholesterol in whites (beta = 4.49, P < 0.001) and Japanese (beta = 3.73, P < 0.01). Marine n-3 PUFAs were significantly positively associated with HDL cholesterol in Japanese (beta = 2.15, P < 0.05), and eicosapentaenoic acid was significantly positively associated with HDL cholesterol in whites (beta = 2.68, P < 0.01).
CONCLUSION: Serum n-6 and n-3 PUFAs are inversely associated with triglycerides across populations.
Authors:
Kenneth R Motoyama; J David Curb; Takashi Kadowaki; Aiman El-Saed; Robert D Abbott; Tomonori Okamura; Rhobert W Evans; Yasuyuki Nakamura; Kim Sutton-Tyrrell; Beatriz L Rodriquez; Aya Kadota; Daniel Edmundowicz; Bradley J Willcox; Jina Choo; Nakata Katsumi; Teruo Otake; Sayaka Kadowaki; Lewis H Kuller; Hirotusgu Ueshima; Akira Sekikawa
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-05-27
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  90     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-22     Completed Date:  2009-07-08     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  49-55     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Alcohol Drinking / epidemiology
Asian Continental Ancestry Group
Cholesterol, HDL / blood
Cross-Sectional Studies
European Continental Ancestry Group
Fasting
Fatty Acids, Omega-3 / blood*
Fatty Acids, Omega-6 / blood*
Humans
Japan / ethnology
Life Style
Lipids / blood*
Middle Aged
Pennsylvania
Questionnaires
Smoking / epidemiology
Triglycerides / blood
United States
Grant Support
ID/Acronym/Agency:
R01 HL068200/HL/NHLBI NIH HHS; R01 HL068200-01A1/HL/NHLBI NIH HHS; R01 HL068200-02/HL/NHLBI NIH HHS; R01 HL068200-03/HL/NHLBI NIH HHS; R01 HL068200-04/HL/NHLBI NIH HHS; R01-HL068200/HL/NHLBI NIH HHS; R01-HL071561/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Cholesterol, HDL; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Lipids; 0/Triglycerides
Comments/Corrections

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