Document Detail


Association of serum myeloperoxidase with the ankle-brachial index and peripheral arterial disease.
MedLine Citation:
PMID:  19651670     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Myeloperoxidase (MPO) is an enzymatic mediator of several inflammatory cascades and higher serum levels have been associated with increased risk of adverse cardiovascular events. We investigated the association of serum MPO with the ankle-brachial index (ABI) and peripheral arterial disease (PAD) in a bi-ethnic cohort of African-Americans and non-Hispanic white individuals. Participants included 1324 African-Americans (mean age 64 years, 71% women) and 1237 non-Hispanic white individuals (mean age 59 years, 57% women) belonging to hypertensive sibships. Serum levels of MPO were measured by solid phase sandwich immunoassay. ABI was measured using a standard protocol and PAD was defined as an ABI < 0.90. Multivariable regression analysis using generalized estimating equations were performed to assess whether serum MPO levels were associated with ABI and the presence of PAD. After adjustment for age and sex, higher MPO levels were significantly associated with lower ABI and the presence of PAD in African-Americans (p = 0.004 and p = 0.005, respectively) and in non-Hispanic white individuals (p = 0.001 and p = 0.016, respectively). After additional adjustment for conventional risk factors (diabetes, smoking status, total and high-density lipoprotein cholesterol, waist circumference, hypertension), prior history of myocardial infarction or stroke, and medication use (statins, aspirin, estrogen), higher MPO levels remained significantly associated with lower ABI and the presence of PAD in both African-Americans (p = 0.008 and p = 0.010, respectively) and non-Hispanic white individuals (p = 0.001 and p = 0.018, respectively). We conclude that higher MPO levels are associated with lower ABI and the presence of PAD in African-Americans and non-Hispanic white individuals.
Authors:
Zeenat Ali; Paul Sarcia; Thomas H Mosley; Venkateswarlu Kondragunta; Iftikhar J Kullo
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Vascular medicine (London, England)     Volume:  14     ISSN:  1358-863X     ISO Abbreviation:  Vasc Med     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-04     Completed Date:  2009-10-08     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9610930     Medline TA:  Vasc Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  215-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
African Americans / statistics & numerical data
Aged
Ankle / blood supply*
Biological Markers / blood
Blood Pressure*
Brachial Artery / physiopathology*
Cross-Sectional Studies
Down-Regulation
European Continental Ancestry Group / statistics & numerical data
Female
Humans
Male
Middle Aged
Peripheral Vascular Diseases / diagnosis*,  enzymology,  ethnology,  physiopathology
Peroxidase / blood*
Predictive Value of Tests
ROC Curve
Regression Analysis
Risk Assessment
Risk Factors
United States / epidemiology
Grant Support
ID/Acronym/Agency:
HL75794/HL/NHLBI NIH HHS; HL81331/HL/NHLBI NIH HHS; R01 HL075794/HL/NHLBI NIH HHS; R01 HL075794-03/HL/NHLBI NIH HHS; U01 HL081331/HL/NHLBI NIH HHS; U01 HL081331-03/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; EC 1.11.1.7/Peroxidase
Comments/Corrections

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