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Association of serum and follicular fluid SHBG levels and SHBG (TAAAA)(n) polymorphism with follicle size in women undergoing ovarian stimulation.
MedLine Citation:
PMID:  20540673     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Objective. Sex hormone-binding globulin (SHBG) is the main transport protein of sex steroids. Recently, it has been found to be produced by granulosa lutein cells, suggesting a local role of SHBG in the ovary. The aim of this study was to investigate whether serum and follicular fluid SHBG levels and SHBG (TAAAA)(n) polymorphism are related to follicle size and pregnancy rate in women undergoing in vitro fertilisation. Methods. The study population consisted of 154 women with tubal and/or male-factor infertility undergoing IVF/ICSI and follicular fluid with oocytes from small (diameter ≤12 mm) and large (diameter ≥18 mm) follicles were studied. Genotyping of SHBG (TAAAA)(n) polymorphism was performed in peripheral blood samples. Serum and follicular fluids were used for hormones determination. Results. Women with short allele genotypes (with less than 8 TAAAA repeats) had higher number of small follicles compared to women with long allele genotypes (5.6 ± 3.9 vs. 3.5 ± 3.2 small follicles, p < 0.003). Follicular fluid SHBG levels correlated positively with serum SHBG levels (p < 0.001) and with the total number of follicles (p < 0.02). Furthermore, small follicles had higher follicular fluid SHBG concentration compared to large follicles (102.9 ± 35.0 nmol/l vs. 85.85 ± 34.88 nmol/l, p < 0.028). Conclusion. SHBG levels and the SHBG (TAAAA)(n) polymorphism are associated with follicle size.
Authors:
Elissavet Hatzi; Ioanna Bouba; Anna Galidi; Leandros Lazaros; Nectaria Xita; Prodromos Sakaloglou; Georgios Kolios; Eleni Bairaktari; Apostolos Kaponis; Konstantinos Zikopoulos; Agathocles Tsatsoulis; Ioannis Georgiou
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Publication Detail:
Type:  Journal Article     Date:  2010-06-14
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  27     ISSN:  1473-0766     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  27-32     Citation Subset:  IM    
Affiliation:
Laboratory of Human Reproductive Genetics, Department of Obstetrics/Gynecology, Medical School, University of Ioannina, Greece.
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