Document Detail

Association of serum fetuin-A levels with mortality in dialysis patients.
MedLine Citation:
PMID:  17342178     Owner:  NLM     Status:  MEDLINE    
Calcifying atherosclerosis is an active process, which is controlled by calcification inhibitors and inducers. Fetuin-A, an acute phase glycoprotein, is one of the more powerful circulating inhibitors of hydroxyapatite formation. A prospective multicenter cohort study was initiated to include both hemodialysis (HD) and peritoneal dialysis (PD) patients in an evaluation of the association of serum fetuin-A levels with both cardiovascular (CV) and non-CV mortality. An increase in the serum fetuin-A concentration of 0.1 g/l was associated with a significant reduction in all-cause mortality of 13%. There was a significant 17% reduction in non-CV mortality and a near significant reduction in CV mortality. This association of fetuin-A and mortality rates was comparable in both HD and PD patients even when corrected for factors, including but not limited to age, gender, primary kidney disease, C-reactive protein levels, and nutritional status. We conclude that serum fetuin-A concentrations may be a general predictor of mortality in dialysis patients.
M M H Hermans; V Brandenburg; M Ketteler; J P Kooman; F M van der Sande; E W Boeschoten; K M L Leunissen; R T Krediet; F W Dekker;
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Publication Detail:
Type:  Journal Article; Multicenter Study     Date:  2007-03-07
Journal Detail:
Title:  Kidney international     Volume:  72     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-07-12     Completed Date:  2007-09-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  202-7     Citation Subset:  IM    
Department of Internal Medicine and Nephrology, Academic Hospital Maastricht, Maastricht, The Netherlands.
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MeSH Terms
Cardiovascular Diseases
Cohort Studies
Middle Aged
Peritoneal Dialysis / mortality
Predictive Value of Tests*
Prospective Studies
Renal Dialysis / mortality*
Survival Analysis
alpha-Fetoproteins / analysis*
Reg. No./Substance:
Comment In:
Kidney Int. 2007 Jul;72(2):137-40   [PMID:  17625580 ]

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