| Association of serum fetuin-A levels with mortality in dialysis patients. | |
| | |
MedLine Citation:
|
PMID: 17342178 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Calcifying atherosclerosis is an active process, which is controlled by calcification inhibitors and inducers. Fetuin-A, an acute phase glycoprotein, is one of the more powerful circulating inhibitors of hydroxyapatite formation. A prospective multicenter cohort study was initiated to include both hemodialysis (HD) and peritoneal dialysis (PD) patients in an evaluation of the association of serum fetuin-A levels with both cardiovascular (CV) and non-CV mortality. An increase in the serum fetuin-A concentration of 0.1 g/l was associated with a significant reduction in all-cause mortality of 13%. There was a significant 17% reduction in non-CV mortality and a near significant reduction in CV mortality. This association of fetuin-A and mortality rates was comparable in both HD and PD patients even when corrected for factors, including but not limited to age, gender, primary kidney disease, C-reactive protein levels, and nutritional status. We conclude that serum fetuin-A concentrations may be a general predictor of mortality in dialysis patients. |
| | |
Authors:
|
M M H Hermans; V Brandenburg; M Ketteler; J P Kooman; F M van der Sande; E W Boeschoten; K M L Leunissen; R T Krediet; F W Dekker; |
Related Documents
:
|
7693298 - Neurochemical substrates of rigidity and chorea in huntington's disease. 2613358 - Dipyridamole thallium-201 perfusion imaging for the study of ischemic heart disease in ... 8195038 - Influence of plasma gsh level on acute radiation mucositis of the oral cavity. 10412788 - Lipoprotein(a) as a risk factor for coronary artery disease in hemodialysis patients. 18209428 - Anemia management in patients with chronic renal disease: current recommendations. 3770278 - Recovery of reproductive function in patients with anorexia nervosa: a 10-year follow-u... |
Publication Detail:
|
Type: Journal Article; Multicenter Study Date: 2007-03-07 |
Journal Detail:
|
Title: Kidney international Volume: 72 ISSN: 0085-2538 ISO Abbreviation: Kidney Int. Publication Date: 2007 Jul |
Date Detail:
|
Created Date: 2007-07-12 Completed Date: 2007-09-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0323470 Medline TA: Kidney Int Country: United States |
Other Details:
|
Languages: eng Pagination: 202-7 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine and Nephrology, Academic Hospital Maastricht, Maastricht, The Netherlands. mherm@sint.azm.nl |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Cardiovascular Diseases Cohort Studies Female Humans Male Middle Aged Mortality Peritoneal Dialysis / mortality Predictive Value of Tests* Prospective Studies Renal Dialysis / mortality* Survival Analysis alpha-Fetoproteins / analysis* |
| Chemical | |
Reg. No./Substance:
|
0/alpha-Fetoproteins |
| Comments/Corrections | |
Comment In:
|
Kidney Int. 2007 Jul;72(2):137-40
[PMID:
17625580
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Phenotypic transitions and fibrosis in diabetic nephropathy.
Next Document: Pathogenesis of poststreptococcal glomerulonephritis a century after Clemens von Pirquet.