Document Detail


Association of serum concentration of soluble class I HLA with HLA allotypes.
MedLine Citation:
PMID:  8623175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We correlated serum concentrations of soluble class I HLA antigens (S-HLA-I) with HLA allotypes in 82 unrelated Caucasian and 58 unrelated African-American putatively normal subjects, as well as in 31 individuals with stable, normally functioning liver transplants. Caucasian and African-American subjects with HLA-A23 or HLA-A24 were high secretors of S-HLA-I. We also observed that some HLA-A allotypes associated with high serum concentrations of S-HLA-I were ethnicity specific. HLA-A33 was associated with high S-HLA-I secretion in African-Americans but not in Caucasians. HLA-A29 was associated with high S-HLA-I secretion in Caucasians but not in African-Americans. All liver transplant recipients studied who were high secretors of S-HLA-I postoperatively carried HLA-A24 or HLA-A29. (There were no HLA-A33 or HLA-A23 allotypes in this group.) The "secretor genes," however, may be autogenous or allogenic (i.e., either donor or recipient HLA-A24 or HLA-A29 resulted in the observed high secretor status in liver transplant recipients after transplantation). It is noteworthy that serum S-HLA-I concentrations were low in all subjects with HLA-A2 regardless of whether the HLA-A2 was of recipient or donor origin. This finding suggests that HLA-A2 could have a suppressive effect on S-HLA-I secretion.
Authors:
I M Adamashvili; P A Fraser; J C McDonald
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Transplantation     Volume:  61     ISSN:  0041-1337     ISO Abbreviation:  Transplantation     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-06-14     Completed Date:  1996-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0132144     Medline TA:  Transplantation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  984-7     Citation Subset:  IM    
Affiliation:
Department of Surgery, Louisiana State University Medical Center, Shreveport 71130, USA.
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MeSH Terms
Descriptor/Qualifier:
African Continental Ancestry Group / genetics
European Continental Ancestry Group / genetics
Histocompatibility Antigens Class I / blood*
Humans
Immunoglobulin Allotypes / blood*
Liver Transplantation / immunology
Solubility
Chemical
Reg. No./Substance:
0/Histocompatibility Antigens Class I; 0/Immunoglobulin Allotypes
Comments/Corrections
Comment In:
Transplantation. 1997 Feb 27;63(4):617   [PMID:  9047163 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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