| Association of serum bone morphogenetic protein 4 levels with obesity and metabolic syndrome in non-diabetic individuals. | |
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MedLine Citation:
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PMID: 21186333 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bone morphogenetic protein 4 (BMP-4) is involved in the earliest stages of adipocyte differentiation and is recognized as an adipogenic factor for white adipose tissue. The association of serum BMP-4 levels with anthropometric and metabolic parameters has not been previously studied. We aimed to explore the relationship of serum BMP-4 levels with obesity and metabolic syndrome. Serum BMP-4 levels were measured in 104 non-diabetic individuals from the Chungju Metabolic Disease Cohort Study. Anthropometric measurements and components of metabolic syndrome were assessed in all patients. Serum BMP-4 levels were significantly increased in individuals with obesity or metabolic syndrome. After adjusting for age and gender, serum BMP-4 levels were positively correlated with body mass index, waist circumference (WC), waist-to-hip ratio, fasting plasma insulin, homeostasis model assessment index, and triglycerides and were negatively correlated with high-density lipoprotein (HDL) cholesterol. Among these parameters, WC and HDL cholesterol were found to be independent contributing factors for serum BMP-4 levels. Serum BMP-4 levels were also significantly higher in subjects with positive diagnostic criteria for each component of metabolic syndrome. The area under the receiver operating characteristic curve for BMP-4 was 0.661 (P = 0.022, 95% CI = 0.528 to 0.794) and the cut-off value was 2.84 pg/mL. This is the first demonstration that serum BMP-4 levels are associated with adiposity, insulin resistance, and the presence of metabolic syndrome. Whether BMP-4 may be involved in the pathogenesis of obesity and metabolic syndrome deserves further investigation. |
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Authors:
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Jang-Won Son; Mee-Kyoung Kim; Yong-Moon Park; Ki-Hyun Baek; Soon-Jib Yoo; Ki-Ho Song; Hyun Shik Son; Kun-Ho Yoon; Won Chul Lee; Bong-Yun Cha; Ho-Young Son; Hyuk-Sang Kwon |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-12-21 |
Journal Detail:
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Title: Endocrine journal Volume: 58 ISSN: 1348-4540 ISO Abbreviation: Endocr. J. Publication Date: 2011 |
Date Detail:
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Created Date: 2011-02-04 Completed Date: 2011-05-16 Revised Date: 2011-06-16 |
Medline Journal Info:
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Nlm Unique ID: 9313485 Medline TA: Endocr J Country: Japan |
Other Details:
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Languages: eng Pagination: 39-46 Citation Subset: IM |
Affiliation:
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Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea, #62 Yeoido-dong, Seoul, Korea. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adiposity Adult Aged Body Mass Index Bone Morphogenetic Protein 4 / blood* Cholesterol, HDL / blood Cohort Studies Fasting Female Humans Insulin / blood Insulin Resistance Male Metabolic Syndrome X / blood* Middle Aged Obesity / blood* Prospective Studies Triglycerides / blood Waist-Hip Ratio |
| Chemical | |
Reg. No./Substance:
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0/Bone Morphogenetic Protein 4; 0/Cholesterol, HDL; 0/Triglycerides; 11061-68-0/Insulin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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