Document Detail

Association of serum bone morphogenetic protein 4 levels with obesity and metabolic syndrome in non-diabetic individuals.
MedLine Citation:
PMID:  21186333     Owner:  NLM     Status:  MEDLINE    
Bone morphogenetic protein 4 (BMP-4) is involved in the earliest stages of adipocyte differentiation and is recognized as an adipogenic factor for white adipose tissue. The association of serum BMP-4 levels with anthropometric and metabolic parameters has not been previously studied. We aimed to explore the relationship of serum BMP-4 levels with obesity and metabolic syndrome. Serum BMP-4 levels were measured in 104 non-diabetic individuals from the Chungju Metabolic Disease Cohort Study. Anthropometric measurements and components of metabolic syndrome were assessed in all patients. Serum BMP-4 levels were significantly increased in individuals with obesity or metabolic syndrome. After adjusting for age and gender, serum BMP-4 levels were positively correlated with body mass index, waist circumference (WC), waist-to-hip ratio, fasting plasma insulin, homeostasis model assessment index, and triglycerides and were negatively correlated with high-density lipoprotein (HDL) cholesterol. Among these parameters, WC and HDL cholesterol were found to be independent contributing factors for serum BMP-4 levels. Serum BMP-4 levels were also significantly higher in subjects with positive diagnostic criteria for each component of metabolic syndrome. The area under the receiver operating characteristic curve for BMP-4 was 0.661 (P = 0.022, 95% CI = 0.528 to 0.794) and the cut-off value was 2.84 pg/mL. This is the first demonstration that serum BMP-4 levels are associated with adiposity, insulin resistance, and the presence of metabolic syndrome. Whether BMP-4 may be involved in the pathogenesis of obesity and metabolic syndrome deserves further investigation.
Jang-Won Son; Mee-Kyoung Kim; Yong-Moon Park; Ki-Hyun Baek; Soon-Jib Yoo; Ki-Ho Song; Hyun Shik Son; Kun-Ho Yoon; Won Chul Lee; Bong-Yun Cha; Ho-Young Son; Hyuk-Sang Kwon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-12-21
Journal Detail:
Title:  Endocrine journal     Volume:  58     ISSN:  1348-4540     ISO Abbreviation:  Endocr. J.     Publication Date:  2011  
Date Detail:
Created Date:  2011-02-04     Completed Date:  2011-05-16     Revised Date:  2011-06-16    
Medline Journal Info:
Nlm Unique ID:  9313485     Medline TA:  Endocr J     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  39-46     Citation Subset:  IM    
Division of Endocrinology and Metabolism, Department of Internal Medicine, The Catholic University of Korea, #62 Yeoido-dong, Seoul, Korea.
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MeSH Terms
Body Mass Index
Bone Morphogenetic Protein 4 / blood*
Cholesterol, HDL / blood
Cohort Studies
Insulin / blood
Insulin Resistance
Metabolic Syndrome X / blood*
Middle Aged
Obesity / blood*
Prospective Studies
Triglycerides / blood
Waist-Hip Ratio
Reg. No./Substance:
0/Bone Morphogenetic Protein 4; 0/Cholesterol, HDL; 0/Triglycerides; 11061-68-0/Insulin

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