Document Detail

Association of serum antibodies to heat-shock protein 65 with borderline hypertension.
MedLine Citation:
PMID:  9039077     Owner:  NLM     Status:  MEDLINE    
Heat-shock proteins protect cells from damage but are also often the target of immune responses in inflammation and may therefore both induce and perpetuate the chronic inflammation characterizing atherosclerosis. Hypertension is a well-established risk factor for atherosclerosis, and recently, borderline hypertension also has been related to atherosclerosis. The present study investigated the possible role of heat-shock proteins in borderline hypertension and their relation to atherosclerosis by investigating antibody titers against the 65-kD heat-shock protein (HSP65). Sixty-six men with borderline hypertension and 67 age-matched normotensive men (diastolic pressure, 85 to 94 and < 80 mm Hg, respectively) were recruited from a population screening program. Titers of antibodies to HSP65 were determined by enzyme-linked immunosorbent assay. The presence of carotid atherosclerosis was determined by B-mode ultrasonography. Twenty-seven individuals had atherosclerotic plaques: 48 were smokers (more than one to two cigarettes per day). Borderline hypertensive men had higher anti-HSP65 reactivity than normotensive control subjects (P = .034). Smokers with atherosclerosis had low levels of antibodies to HSP65 compared with nonsmokers with atherosclerosis (P = .002). Furthermore, when high-risk individuals (borderline hypertension plus plaque, n = 15) were compared with matched low-risk individuals (normotensive with no plaque, n = 15), the high-risk men had significantly enhanced antibody titers to HSP65 (P = .041). In conclusion, we demonstrate that serum antibody titers to HSP65 are enhanced in individuals with borderline hypertension, which may indicate an ongoing immune reaction in the artery wall.
J Frostegård; C Lemne; B Andersson; R van der Zee; R Kiessling; U de Faire
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  29     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1997 Jan 
Date Detail:
Created Date:  1997-03-10     Completed Date:  1997-03-10     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  40-4     Citation Subset:  IM    
Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
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MeSH Terms
Antibodies / blood*
Arteriosclerosis / etiology*,  immunology,  ultrasonography
Bacterial Proteins*
Body Constitution
Carotid Arteries / pathology,  ultrasonography
Case-Control Studies
Chaperonin 60
Chaperonins / immunology*
Enzyme-Linked Immunosorbent Assay
Hyperinsulinism / complications
Hyperlipidemias / complications
Hypertension / blood,  complications*,  immunology
Middle Aged
Risk Factors
Smoking / immunology
Reg. No./Substance:
0/Antibodies; 0/Bacterial Proteins; 0/Chaperonin 60; 0/heat-shock protein 65, Mycobacterium; EC 3.6.1.-/Chaperonins

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