| Association of serum albumin with blood pressure in the normative aging study. | |
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MedLine Citation:
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PMID: 1288276 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Little is known regarding serum albumin's epidemiologic relation to chronic disease. The relation of serum albumin to blood pressure was assessed in a longitudinal study of men who have been seen at 3- to 5-year intervals since the early 1960s. The authors analyzed data from over 20 years of observation using cross-sectional multiple regression models of blood pressure that allow for the correlation between repeated measures on the same individual (GLMIC models), longitudinal GLMIC models that incorporate terms for the interaction of time with serum albumin at baseline, and models of the slope of individuals' blood pressure over time. Serum albumin levels were found to have a consistently strong relation with both systolic blood pressure and diastolic blood pressure in the cross-sectional GLMIC models only. This relation did not change appreciably when covariates for age, body mass index, alcohol ingestion, smoking, serum calcium, hematocrit, heart rate, and antihypertensive medications were added. A rise in serum albumin of 1 g/dl was associated with 1.79-mmHg and 0.91-mmHg increases in systolic blood pressure and diastolic blood pressure, respectively. This phenomenon may be related to experimental studies linking tryptophan, the only amino acid to bind noncovalently to serum albumin, to a blood pressure-lowering effect mediated by promotion of 5-hydroxytryptamine synthesis in the brain. |
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Authors:
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H Hu; D Sparrow; S Weiss |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: American journal of epidemiology Volume: 136 ISSN: 0002-9262 ISO Abbreviation: Am. J. Epidemiol. Publication Date: 1992 Dec |
Date Detail:
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Created Date: 1993-03-16 Completed Date: 1993-03-16 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7910653 Medline TA: Am J Epidemiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1465-73 Citation Subset: IM |
Affiliation:
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Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aging / physiology* Blood Pressure / physiology* Calcium / blood Cross-Sectional Studies Humans Linear Models Longitudinal Studies Male Middle Aged Serum Albumin / analysis* |
| Grant Support | |
ID/Acronym/Agency:
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2 P30 ES 00002/ES/NIEHS NIH HHS; ES05257-01A1/ES/NIEHS NIH HHS; HL37871/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Serum Albumin; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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