Document Detail


Association of serotonin transporter promoter regulatory region polymorphism and cerebral activity to visual presentation of food.
MedLine Citation:
PMID:  18476994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent functional magnetic resonance imaging (fMRI) studies have revealed links between genetic polymorphisms and cognitive and behavioural processes. Serotonin is a classical neurotransmitter of central nervous system, and it is connected to the control of appetite and satiety. In this study, the relationship between the functional variation in the serotonin transporter gene and the activity in the left posterior cingulate cortex (PCC), a brain area activated by visual food stimuli was explored. Thirty subjects underwent serial fMRI studies and provided DNA for genetic analyses. Subjects homozygous for the long allele exhibited greater left PCC activity in the comparison food > non-food compared with individuals heterozygous or homozygous for the short allele. The association between genotype and activation was linear, the subjects with two copies of the long allele variant having the strongest activation. These results demonstrate the possible genetically driven variation in the response of the left PCC to visual presentation of food in humans.
Authors:
Salla Kaurijoki; Jyrki T Kuikka; Eini Niskanen; Synnöve Carlson; Kirsi H Pietiläinen; Ullamari Pesonen; Jaakko M Kaprio; Aila Rissanen; Jari Tiihonen; Leila Karhunen
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical physiology and functional imaging     Volume:  28     ISSN:  1475-0961     ISO Abbreviation:  Clin Physiol Funct Imaging     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-07-02     Completed Date:  2008-11-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  101137604     Medline TA:  Clin Physiol Funct Imaging     Country:  England    
Other Details:
Languages:  eng     Pagination:  270-6     Citation Subset:  IM    
Affiliation:
Department of Clinical Nutrition, University of Kuopio, Finland.
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MeSH Terms
Descriptor/Qualifier:
Adult
Alleles
Analysis of Variance
Appetite
Brain Mapping
Female
Food*
Gyrus Cinguli / physiology*
Humans
Magnetic Resonance Imaging
Male
Polymorphism, Genetic*
Promoter Regions, Genetic*
Regression Analysis
Serotonin Plasma Membrane Transport Proteins / genetics*,  physiology
Visual Perception*
Grant Support
ID/Acronym/Agency:
AA08315/AA/NIAAA NIH HHS; AA12502/AA/NIAAA NIH HHS
Chemical
Reg. No./Substance:
0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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