Document Detail


Association of the serotonin transporter promoter regulatory region polymorphism and obsessive-compulsive disorder.
MedLine Citation:
PMID:  10523819     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although modulation of symptoms of obsessive-compulsive disorder (OCD) by serotonergic agents is well established, it is unclear whether an abnormality in the central serotonergic system is involved in its etiology. The serotonin (5-HT) transporter (5-HTT), which is the key modulator of serotonergic neurotransmission, is the target for serotonin reuptake inhibiting drugs (SRIs) that are uniquely effective in the treatment of OCD. In this preliminary study we report an association of a functional polymorphism in the 5-HTT 5' regulatory-region and OCD. Seventy-five OCD Caucasian patients and 397 ethnically-matched individuals from a non-patient control group were genotyped for the 5-HTTLPR. Population-based association analysis revealed that patients with OCD were more likely to carry two copies of the long allele (l) as compared to controls (46.7% vs 32.3%: chi2 = 5.19, P = 0.023). This finding replicates a recent family-based study of this polymorphism in OCD, and thus indicates that the 5-HTTLPR may be associated with susceptibility to OCD.
Authors:
D Bengel; B D Greenberg; G Corá-Locatelli; M Altemus; A Heils; Q Li; D L Murphy
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Molecular psychiatry     Volume:  4     ISSN:  1359-4184     ISO Abbreviation:  Mol. Psychiatry     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-12-10     Completed Date:  1999-12-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9607835     Medline TA:  Mol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  463-6     Citation Subset:  IM    
Affiliation:
Laboratory of Clinical Science, National Institute of Mental Health, NIH, Bethesda, MD, 20892-1264, USA. dietmar.bengel@mail.uni-wuerzburg.de
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MeSH Terms
Descriptor/Qualifier:
Alleles
Carrier Proteins / genetics*
Case-Control Studies
Chi-Square Distribution
European Continental Ancestry Group / genetics
Female
Gene Frequency
Genetic Predisposition to Disease
Genotype
Humans
Linkage (Genetics)*
Male
Membrane Glycoproteins / genetics*
Membrane Transport Proteins*
Nerve Tissue Proteins*
Obsessive-Compulsive Disorder / genetics*
Polymorphism, Genetic*
Promoter Regions, Genetic / genetics*
Serotonin Plasma Membrane Transport Proteins
Chemical
Reg. No./Substance:
0/Carrier Proteins; 0/Membrane Glycoproteins; 0/Membrane Transport Proteins; 0/Nerve Tissue Proteins; 0/SLC6A4 protein, human; 0/Serotonin Plasma Membrane Transport Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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