Document Detail

Association of semen quality and occupational factors: comparison of case-control analysis and analysis of continuous variables.
MedLine Citation:
PMID:  9457925     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To compare two statistical approaches, case-control and analysis of continuous parameters of semen, in examining the relationship between occupational exposures and male reproductive function. DESIGN: Case-control study. SETTING: Males providing semen samples at a university infertility clinic. PATIENT(S): Nonvasectomized males who provided at least one semen sample at an infertility clinic. MAIN OUTCOME MEASURE(S): Standard clinical semen analysis. RESULT(S): Analyses using a dichotomous dependent variable did not uncover significant associations between any occupational factor and infertility case status. However, linear models incorporating continuous variables identified a number of occupational factors that were associated with specific parameters of semen. A reduction in percentage of progressive sperm and an increase in percentage of coiled tail sperm defects in welders, compared with unexposed subjects, were found. Significant dose-response relationships between level of perceived job stress and percentage of progressive sperm, total motile count, morphology, abnormal heads, and coiled tail defects were found. CONCLUSION(S): The findings suggest that subtle changes in semen variables, possibly associated with workplace exposure, may be detected only with parametric analyses of continuous variables of semen.
P L Bigelow; J Jarrell; M R Young; T J Keefe; E J Love
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Fertility and sterility     Volume:  69     ISSN:  0015-0282     ISO Abbreviation:  Fertil. Steril.     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-03-04     Completed Date:  1998-03-04     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  11-8     Citation Subset:  IM    
Department of Community Health Sciences, The University of Calgary, Faculty of Medicine, Alberta, Canada.
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MeSH Terms
Case-Control Studies
Infertility, Male / etiology*,  physiopathology*
Middle Aged
Semen / physiology*
Statistics as Topic / methods
Stress, Physiological / physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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