Document Detail

Association of salivary levels of cortisol and dehydroepiandrosterone with periodontitis in older Japanese adults.
MedLine Citation:
PMID:  17760547     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The relationship between periodontitis and psychoneuroimmunologic variables, such as stress-related hormones, is poorly understood. The purpose of this cross-sectional study was to investigate the associations between two kinds of stress-related hormones, cortisol and dehydroepiandrosterone (DHEA), and periodontitis in healthy community-dwelling elderly subjects aged > or =60 years. METHODS: A total of 171 subjects (85 males and 86 females) participated in this study. The subjects were independently living elderly people with a mean age of 68.4 (+/- 4.46) years. Stimulated whole saliva samples were collected, and hormone levels were determined. A medical questionnaire regarding medical conditions, lifestyle, and psychosocial stress also was administered. The clinical examinations included probing depth (PD), bleeding on probing, and clinical attachment level (CAL). RESULTS: There was a positive correlation between hormone levels and PD and CAL values. When the subjects were divided into two groups based on periodontitis severity, hormone levels were significantly higher in subjects with severe PD or CAL. Multiple regression analysis showed that higher cortisol and DHEA levels were associated significantly with greater numbers of teeth with severe PD or CAL, after adjusting for confounding variables. CONCLUSIONS: These results suggested close relationships between the extent and severity of periodontitis and salivary levels of cortisol and DHEA in healthy elderly subjects. To the best of our knowledge, this is the first report on the association between the levels of DHEA and extensive periodontitis.
Aiko Ishisaka; Toshihiro Ansai; Inho Soh; Kiyotoshi Inenaga; Akihiro Yoshida; Chieko Shigeyama; Shuji Awano; Tomoko Hamasaki; Kazuo Sonoki; Yutaka Takata; Tadamichi Takehara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of periodontology     Volume:  78     ISSN:  0022-3492     ISO Abbreviation:  J. Periodontol.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-08-31     Completed Date:  2007-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1767-73     Citation Subset:  D; IM    
Division of Community Oral Health Science, Department of Health Promotion, Kyushu Dental College, Kitakyushu, Japan.
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MeSH Terms
Age Factors
Aged, 80 and over
Cross-Sectional Studies
Dehydroepiandrosterone / analysis,  metabolism*
Hydrocortisone / analysis,  metabolism*
Middle Aged
Periodontal Attachment Loss / metabolism
Periodontitis / complications,  metabolism*
Regression Analysis
Saliva / chemistry*
Statistics, Nonparametric
Stress, Psychological / complications,  metabolism
Reg. No./Substance:
50-23-7/Hydrocortisone; 53-43-0/Dehydroepiandrosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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