Document Detail

Association of reduced extracellular brain ammonia, lactate, and intracranial pressure in pigs with acute liver failure.
MedLine Citation:
PMID:  17705298     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: The observation that brain oxygen consumption and mitochondrial complex enzyme activity changed in parallel in both ALF- and MARS-treated animals indicates that the attenuation of increased extracellular brain ammonia (and extracellular brain glutamate) in the MARS-treated animals reduces energy demand and increases supply, resulting in attenuation of increased extracellular brain lactate. The mechanism of how MARS reduces extracellular brain ammonia requires further investigation.
Christopher Rose; Lars M Ytrebø; Nathan A Davies; Sambit Sen; Geir I Nedredal; Mireille Belanger; Arthur Revhaug; Rajiv Jalan
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Publication Detail:
Type:  Evaluation Studies; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  46     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-01-10     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1883-92     Citation Subset:  IM    
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MeSH Terms
Ammonia / analysis*
Brain Chemistry*
Disease Models, Animal
Extracellular Space
Glutamic Acid / analysis
Glutamine / analysis
Intracranial Pressure*
Lactic Acid / analysis*
Liver Failure, Acute / therapy*
Sorption Detoxification*
Reg. No./Substance:
0RH81L854J/Glutamine; 33X04XA5AT/Lactic Acid; 3KX376GY7L/Glutamic Acid; 7664-41-7/Ammonia

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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