Document Detail

Association of pseudoexfoliation syndrome with increased vascular risk.
MedLine Citation:
PMID:  9372724     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To examine vascular associations with pseudoexfoliation syndrome in view of the wide-spread elastosis now demonstrated in this disorder that affects many tissues, including vessel walls. METHODS: The Blue Mountains Eye Study is a population-based study of eye disease in an area west of Sydney, Australia. Of 4433 eligible persons aged 49 years or older, 3,654 (82.4%) participated. Signs of pseudoexfoliation were graded clinically, after excluding 108 people who had bilateral cataract surgery. RESULTS: Pseudoexfoliation was present in 81 (2.3%) of 3546 participants aged 49 years or older. The prevalence of pseudoexfoliation increased with age and was higher in women and in people with glaucoma. Pseudoexfoliation was statistically significantly associated with a history of angina or hypertension or a combined history of angina, acute myocardial infarction, or stroke. CONCLUSION: Slit-lamp signs of pseudoexfoliation may identify individuals with an increased vascular risk.
P Mitchell; J J Wang; W Smith
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of ophthalmology     Volume:  124     ISSN:  0002-9394     ISO Abbreviation:  Am. J. Ophthalmol.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1997-12-01     Completed Date:  1997-12-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370500     Medline TA:  Am J Ophthalmol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  685-7     Citation Subset:  AIM; IM    
Department of Ophthalmology, University of Sydney, NSW, Australia.
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MeSH Terms
Aged, 80 and over
Australia / epidemiology
Exfoliation Syndrome / complications,  epidemiology*
Middle Aged
Odds Ratio
Risk Factors
Vascular Diseases / complications,  epidemiology*

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