Document Detail


Association of (pro)renin receptor gene polymorphism with blood pressure in Caucasian men.
MedLine Citation:
PMID:  21346687     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The renin-angiotensin system is a major regulatory system of cardiovascular and renal function. Recently, (pro)renin receptor [(P)RR] was identified as new component of the renin-angiotensin system. The IVS5+169C>T polymorphism of the (P)RR gene was shown to be associated with blood pressure (BP) in Japanese men, but no data are available for Caucasians. Hence, we genotyped the IVS5+169C>T polymorphism of the (P)RR gene in 266 Caucasian men with normal or mildly elevated BP and without any medication. Office BP was measured according to current guidelines. Office and resting systolic BP was lower in C-allele than in T-allele carriers (P<0.05) of the (P)RR gene, with no difference in diastolic BP and heart rate. Serum aldosterone was also lower in C-allele than in T-allele carriers (P<0.05). These findings indicate that C-allele carriers have lower systolic BP than T-allele carriers. Thus, our data suggest that (P)RR influences BP regulation in Caucasian men, potentially through altered aldosterone release.
Authors:
Christian Ott; Markus P Schneider; Christian Delles; Markus P Schlaich; Karl F Hilgers; Roland E Schmieder
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacogenetics and genomics     Volume:  21     ISSN:  1744-6880     ISO Abbreviation:  Pharmacogenet. Genomics     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-05-10     Completed Date:  2011-08-18     Revised Date:  2011-10-02    
Medline Journal Info:
Nlm Unique ID:  101231005     Medline TA:  Pharmacogenet Genomics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  347-9     Citation Subset:  IM    
Affiliation:
Department of Nephrology and Hypertension, University of Erlangen-Nürnberg, Krankenhausstrasse 12, Erlangen, Germany.
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MeSH Terms
Descriptor/Qualifier:
Aldosterone / metabolism
Blood Pressure / genetics*
Diabetes Mellitus, Type 2 / physiopathology
European Continental Ancestry Group / genetics*
Gene Frequency
Genotype
Hemodynamics
Humans
Hypercholesterolemia / physiopathology
Hypertension / physiopathology
Male
Metabolic Syndrome X / physiopathology
Middle Aged
Polymorphism, Genetic / genetics*
Receptors, Cell Surface / genetics*
Chemical
Reg. No./Substance:
0/Receptors, Cell Surface; 0/prorenin receptor; 52-39-1/Aldosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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