| Association of primary antiphospholipid syndrome with inherited activated protein C resistance. | |
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MedLine Citation:
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PMID: 9632093 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A 65-year-old man had had arterial thromboses of the lower limbs and cerebral region for several years; tests revealed anticardiolipin, antiphosphatidylserine, anti-beta2-glycoprotein I antibodies, and lupus anticoagulant. As well, both phenotypic and genotypic resistance to activated protein C was found. Antiphospholipid antibodies have been reported to interfere in different ways with the functions of protein C; in our patient the simultaneous existence of inherited resistance to activated protein C could account for the thrombophilic status underlying the diffuse and serious arterial thromboses. |
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Authors:
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U Picillo; D De Lucia; E Palatiello; A Scuotto; M R Marcialis; S Pezzella; G Tirri |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: The Journal of rheumatology Volume: 25 ISSN: 0315-162X ISO Abbreviation: J. Rheumatol. Publication Date: 1998 Jun |
Date Detail:
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Created Date: 1998-08-24 Completed Date: 1998-08-24 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7501984 Medline TA: J Rheumatol Country: CANADA |
Other Details:
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Languages: eng Pagination: 1232-4 Citation Subset: IM |
Affiliation:
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Institute of Clinical Medicine, Rheumatology Unit, Faculty of Medicine, 2nd University of Naples, Napoli, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antibodies, Anticardiolipin / analysis Antibodies, Antiphospholipid / analysis Antiphospholipid Syndrome / blood, complications*, pathology Factor V / genetics* Glycoproteins / immunology Humans Lupus Coagulation Inhibitor / blood Magnetic Resonance Imaging Male Mutation* Protein C / genetics* Thromboembolism / complications*, genetics, pathology Thrombophilia / complications*, genetics, pathology beta 2-Glycoprotein I |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Anticardiolipin; 0/Antibodies, Antiphospholipid; 0/Glycoproteins; 0/Lupus Coagulation Inhibitor; 0/Protein C; 0/beta 2-Glycoprotein I; 0/factor V Leiden; 9001-24-5/Factor V |
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