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Association of preprocedural low-density lipoprotein cholesterol levels with myocardial injury after elective percutaneous coronary intervention.
MedLine Citation:
PMID:  25110224     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
BACKGROUND: Lower levels of low-density lipoprotein cholesterol (LDL-C) are associated with less cardiovascular risk in patients with coronary artery disease.
OBJECTIVES: To assess whether lower preprocedural LDL-C levels are associated with less risk of periprocedural myocardial injury in patients undergoing elective percutaneous coronary intervention (PCI).
METHODS: We enrolled 2529 consecutive patients with normal preprocedural cardiac troponin I (cTnI) who successfully underwent elective PCI. The association between preprocedural LDL-C levels and peak cTnI levels within 24 hours after PCI was evaluated.
RESULTS: Preprocedural LDL-C levels were correlated to postprocedural cTnI levels (r = 0.059, P = .003). In the multivariable model, preprocedural LDL-C levels between 70 and 99 mg/dL were associated with less risk of postprocedural cTnI elevation above 1 × upper limit of normal (ULN) (odds ratio [OR]: 0.804; 95% confidence interval [CI]: 0.663-0.975; P = .027) up to 15 × ULN (OR: 0.709; 95% CI: 0.530-0.949; P = .021) compared with preprocedural LDL-C levels ≥100 mg/dL. Moreover, preprocedural LDL-C levels <70 mg/dL were more strongly associated with less risk of postprocedural cTnI elevation above 1 × ULN (OR: 0.736; 95% CI: 0.584-0.927; P = .009) up to 15 × ULN (OR: 0.655; 95% CI: 0.452-0.950; P = .026).
CONCLUSIONS: Lower preprocedural LDL-C levels were associated with less risk of periprocedural myocardial injury in patients undergoing elective PCI.
Authors:
Xiao-Lin Li; Jian-Jun Li; Yuan-Lin Guo; Cheng-Gang Zhu; Rui-Xia Xu; Sha Li; Ping Qing; Na-Qiong Wu; Li-Xin Jiang; Bo Xu; Run-Lin Gao
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Publication Detail:
Type:  Journal Article     Date:  2014-04-15
Journal Detail:
Title:  Journal of clinical lipidology     Volume:  8     ISSN:  1933-2874     ISO Abbreviation:  J Clin Lipidol     Publication Date:    2014 Jul-Aug
Date Detail:
Created Date:  2014-08-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101300157     Medline TA:  J Clin Lipidol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  423-32     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 National Lipid Association. Published by Elsevier Inc. All rights reserved.
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