| Association of prematurity and neonatal infection with neurologic morbidity in very low birth weight infants. | |
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MedLine Citation:
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PMID: 12798532 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To identify risk factors predictive of neurologic morbidity in very low birth weight (VLBW) infants. METHODS: This is a case-control study of all infants weighing 1500 g or less admitted to a single tertiary neonatal intensive care unit between April 1999 and December 2001. The case group were those neonates with neurologic morbidity including intraventricular hemorrhage, seizures, hydrocephalus, and periventricular leukomalacia. The control group were those without neurologic morbidity. Wilcoxon rank-sum, Fisher exact test, chi(2), and univariate and stepwise multiple logistic regression were performed, with P < 0.05 considered significant. RESULTS: Of 213 VLBW infants, 77 had neurologic morbidity: 61 had intraventricular hemorrhage, eight had seizures, 13 had hydrocephalus, and nine had periventricular leukomalacia. Several infants had more than one morbidity. Gestational age (odds ratio [OR] 0.95; 95% confidence interval [CI] 0.94, 0.96; P <.005), birth weight (OR 0.62; 95% CI 0.49, 0.79; P <.005), and neonatal infection (OR 1.36; 95% CI 1.17, 1.58; P <.005) were highly associated with neurologic morbidity. There was no difference in mean umbilical arterial cord pH (7.25 +/- 0.15, 7.28 +/- 0.09, P =.45) or base excess (-3.8 +/- 4.8 mEq/L, -2.3 +/- 3.0, P =.10). Only three of 52 infants (5.8%) in the case group had an umbilical arterial pH of less than 7. CONCLUSION: Prematurity and neonatal infection were the dominant factors associated with neurologic morbidity in VLBW infants. Intrapartum acidosis occurred in less than 6% of those with neurologic morbidity. |
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Authors:
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Cynthia J Holcroft; Karin J Blakemore; Marilee Allen; Ernest M Graham |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Obstetrics and gynecology Volume: 101 ISSN: 0029-7844 ISO Abbreviation: Obstet Gynecol Publication Date: 2003 Jun |
Date Detail:
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Created Date: 2003-06-11 Completed Date: 2003-07-03 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0401101 Medline TA: Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 1249-53 Citation Subset: AIM; IM |
Affiliation:
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Department of Gynecology-Obstetrics, Johns Hopkins University School of Medicine, Baltimore 21287, Maryland, USA. cholcroft@jhmi.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain Diseases / etiology* Case-Control Studies Chorioamnionitis / complications* Female Fetal Blood / chemistry Fetal Hypoxia / complications Humans Hydrocephalus / etiology Hydrogen-Ion Concentration Infant, Newborn Infant, Premature Infant, Premature, Diseases / etiology* Infant, Very Low Birth Weight* Infection / complications* Intracranial Hemorrhages / etiology Leukomalacia, Periventricular / etiology Logistic Models Male Pregnancy Risk Factors Seizures / etiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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