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Association of premature androgenetic alopecia and metabolic syndrome in a young Indian population.
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MedLine Citation:
PMID:  25191037     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Although evidences for association of androgenetic alopecia (AGA) with metabolic syndrome (MetS) are accruing, inconclusiveness with respect to the gender specificity and differential association of MetS with increasing severity of AGA continues to persist. Furthermore, data specific to Indian settings are relatively sparse.
AIMS: The present study aimed at assessing the frequency of MetS in individuals with early AGA in Indian settings.
SETTINGS AND DESIGN: A case-control study was conducted at a trichology clinic in Bengaluru between April 2012 and September 2012 with a total of 85 cases of AGA and 85 age-matched controls.
MATERIALS AND METHODS: The Norwood-Hamilton classification was used to assess the grade of AGA. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III criteria. Blood pressure, blood glucose, lipid parameters, and body mass index along with anthropometric measurements were assessed in all study participants.
STATISTICAL ANALYSIS USED: Chi-square test was used to compare proportions between groups. Means were compared between groups using Student's t-test.
RESULTS: MetS was seen in a higher proportion of patients with AGA (43.5%) as compared to the control group (2.4%) and the differences were statistically significant (P < 0.001). As compared to controls, patients with AGA had higher triglycerides (P < 0.001), systolic blood pressure (P < 0.001), diastolic blood pressure (P < 0.001) along with significantly lower high-density lipoprotein cholesterol levels (P < 0.001). Severity of AGA was not associated with MetS.
CONCLUSIONS: AGA is associated with MetS in male Indian patients aged <30 years. Studies with large sample sizes may be required to conclusively define any putative associations between AGA grades and MetS.
Authors:
S Chakrabarty; R Hariharan; Dg Gowda; Hemalini Suresh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of trichology     Volume:  6     ISSN:  0974-7753     ISO Abbreviation:  Int J Trichology     Publication Date:  2014 Apr 
Date Detail:
Created Date:  2014-09-05     Completed Date:  2014-09-05     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  101534370     Medline TA:  Int J Trichology     Country:  India    
Other Details:
Languages:  eng     Pagination:  50-3     Citation Subset:  -    
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Journal Information
Journal ID (nlm-ta): Int J Trichology
Journal ID (iso-abbrev): Int J Trichology
Journal ID (publisher-id): IJT
ISSN: 0974-7753
ISSN: 0974-9241
Publisher: Medknow Publications & Media Pvt Ltd, India
Article Information
Copyright: © International Journal of Trichology
open-access:
Print publication date: Season: Apr-Jun Year: 2014
Volume: 6 Issue: 2
First Page: 50 Last Page: 53
PubMed Id: 25191037
ID: 4154150
Publisher Id: IJT-6-50
DOI: 10.4103/0974-7753.138586

Association of Premature Androgenetic Alopecia and Metabolic Syndrome in a Young Indian Population
S Chakrabartyaff1
R Hariharan1
DG Gowdaaff1
Hemalini Sureshaff1
Hairline International Hair Clinic, Bengaluru, Karnataka, India
1Department of Observational, Research Clinibyte Health Sciences Pvt. Ltd., Bengaluru, Karnataka, India
Correspondence: Address for correspondence: Dr. S Chakrabarty, Hairline International Hair Clinic, 199, 16th Main Road, 4th ‘T’ Block, Jayanagar, Bengaluru - 560 041, Karnataka, India. E-mail: dr.swagata@hairline.in

INTRODUCTION

Numerous studies have documented the association of androgenetic alopecia (AGA) with cancers,[1, 2] coronary artery disease,[3] diabetes,[3, 4] hypertension,[5] and metabolic syndrome (MetS).[6, 7, 8]

Despite a growing body of evidences for the association between AGA and MetS, elements of inconclusiveness persist in the literature.[9, 10] The association between AGA and MetS may be gender-specific to females.[11] Furthermore, the association of MetS with increasing severity of AGA is inconclusive.[12, 13]

Despite the high burden of AGA[14] and MetS,[15] India-specific data on the subject are relatively sparse.

On these premises, we investigated the association of AGA with MetS among Indian patients through a case-control study.


MATERIALS AND METHODS

A 6-month long case-control study was conducted at an out-patient trichology clinic in Bengaluru, India between April 2012 and September 2012. The study was approved by the Institutional Ethics Committee. A total of 85 male subjects (aged < 30 years) with AGA were included in the study. Subjects with scarring alopecia, alopecia areata, or other systemic disorders were excluded. The study also included 85 age-matched controls. A signed informed consent was obtained from all the participants in the study.

The Norwood-Hamilton classification was used to assess the grade of AGA.[16] MetS was defined according to the National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) criteria.[17]

Blood pressure, blood glucose, lipid parameters, and body mass index (BMI) along with anthropometric measurements (height, weight and waist circumference) were assessed in all the study participants. Blood pressure was recorded as the mean of three consecutive readings during a period of 1 month. Fasting blood sugar (FBS) and fasting insulin were determined using glucose hexokinase reagent and chemiluminescence immunoassay, respectively. The homeostatic model assessment-estimated insulin resistance (HOMA-IR) was calculated with a cut-off value of 1.5. High-density lipoprotein cholesterol (HDL-C) (by direct enzymatic method), low-density lipoprotein (LDL) (derived), very-LDL (derived), and triglycerides (using glycerol phosphate oxidase trinder reagent) were all examined in the fasting state.

The data were analyzed using Statistical Package for the Social Sciences version 22.0 (SPSS Inc., Chicago, IL, USA). The mean ± standard deviation (SD), and the number and percentage of participants were tabulated. Means were compared across groups using t-test and proportions were compared with Karl Pearson's Chi-square test. Statistical significance was set at P < 0.05.


RESULTS

A total of 170 subjects was assigned to the study. The mean age of subjects with AGA was 26.44 ± 2.64 and that of the participants in the control group was 25.65 ± 3.19 years. Age did not differ significantly between groups (P = 0.081). Table 1 presents the mean (SD) of height, weight, and BMI along with other indices of MetS such as waist circumference, blood pressure, blood glucose, and lipid parameters observed in the case and control groups.

Significant differences were noted between groups for all the variables except waist circumference and FBS. MetS was significantly higher in patients with AGA when compared to subjects in the control group [Table 2].

However, there was no relationship between AGA severity and MetS [Table 3].

Table 4 presents the comparative proportions of subjects fulfilling the NCEP-ATP III criteria for individual components of MetS in the AGA and control groups. Results of this study indicate that proportions of patients with a waist circumference > 102 cm and FBS ≥ 110 mg/dL were not significantly different between case and control groups. On the other hand, proportions of patients with blood pressure (≥130/≥85 mmHg), HDL-C (<40 mg/dL) and triglyceride levels (≥150 mg/dL) were significantly higher in the AGA group when compared to controls.


DISCUSSION

In a recent case-control study, Acibucu et al. reported that 25% (20/60) patients with AGA had MetS as compared to 10.4% (5/48) among controls.[13] Another study by Arias-Santiago et al. indicated that criteria for MetS were met by 57.1% of the patients with AGA compared to 14.3% of the controls.[18] Results of the current study are in conformity with these findings. However, Yi et al. indicate that the association between MetS and AGA may be gender-specific; in their study, significant associations were seen only in females.[11] The current study, along with others, demonstrates a significant association in males as well. Nevertheless, gender-specific associations warrant further investigation.

Proportions of patients with higher blood pressure and triglyceride levels and lower HDL-C levels were significantly more in the AGA group when compared to controls. Ahouansou et al. posit a strong association between AGA and hypertension.[5] Furthermore, in a recent study, Agac et al. indicate a higher frequency of abnormal cardio-ankle vascular index in patients with AGA.[19] It could be possible that AGA-related increases in arterial stiffness links AGA and hypertension.

Arias-Santiago et al. reported significant higher triglyceride values in males with AGA as compared to controls.[20] Su and Chen underscores the particular importance of low HDL-C levels in the association between MetS and AGA.[8] Our findings seem to be in agreement with these lines of evidence at least to the extent that significantly lower HDL-C levels are seen in patients with AGA when compared to controls.

The current study could not identify any significant association with respect to FBS in both the groups. However, a significant association was noticed with respect to HOMA-IR (P < 0.001) in patients with AGA when compared to the control group. This is similar to the observations made in the epidemiological study by Gonzαlez-Gonzαlez et al., which reported HOMA-IR to be higher patients with AGA.[21]

The NCEP-ATP guidelines indicate that although both overweight and obesity are associated with MetS, abdominal obesity is more highly correlated with the metabolic risk factors when compared to elevated BMI.[17] In the current study, BMI along with height and weight were significantly different between groups. However, waist circumference was not significantly different between groups and was not associated with MetS.

Similar to observations of Pengsalae et al.,[6] the results of the current study could not find any relationship between AGA severity and MetS. Although this may indicate a lack of association, it is also possible that sample size within the stages of AGA is small to conclusively identify any putative associations.[13]


CONCLUSION

It appears that AGA is associated with MetS in male Indian patients aged <30 years. Studies with large sample sizes may be required to conclusively define any putative associations between AGA grades and MetS.


Notes

Source of Support: Nil

Conflict of Interest: None declared.

REFERENCES
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2. Arias-Santiago S,Arrabal-Polo MA,Buendía-Eisman A,Arrabal-Martín M,Gutiérrez-Salmerón MT,Girón-Prieto MS,et al. Androgenetic alopecia as an early marker of benign prostatic hyperplasiaJ Am Acad DermatolYear: 201266401821835498
3. Su LH,Chen LS,Lin SC,Chen HH. Association of androgenetic alopecia with mortality from diabetes mellitus and heart diseaseJAMA DermatolYear: 2013149601623677087
4. Hirsso P,Laakso M,Matilainen V,Hiltunen L,Rajala U,Jokelainen J,et al. Association of insulin resistance linked diseases and hair loss in elderly men. Finnish population-based studyCent Eur J Public HealthYear: 200614788116830609
5. Ahouansou S,Le Toumelin P,Crickx B,Descamps V. Association of androgenetic alopecia and hypertensionEur J DermatolYear: 200717220217478384
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7. Mumcuoglu C,Ekmekci TR,Ucak S. The investigation of insulin resistance and metabolic syndrome in male patients with early-onset androgenetic alopeciaEur J DermatolYear: 201121798221224180
8. Su LH,Chen TH. Association of androgenetic alopecia with metabolic syndrome in men: A community-based surveyBr J DermatolYear: 2010163371720426781
9. Abdel Fattah NS,Darwish YW. Androgenetic alopecia and insulin resistance: Are they truly associated?Int J DermatolYear: 2011504172221413951
10. Nabaie L,Kavand S,Robati RM,Sarrafi-Rad N,Kavand S,Shahgholi L,et al. Androgenic alopecia and insulin resistance: Are they really related?Clin Exp DermatolYear: 200934694719323660
11. Yi SM,Son SW,Lee KG,Kim SH,Lee SK,Cho ER,et al. Gender-specific association of androgenetic alopecia with metabolic syndrome in a middle-aged Korean populationBr J DermatolYear: 20121673061322486172
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13. Acibucu F,Kayatas M,Candan F. The association of insulin resistance and metabolic syndrome in early androgenetic alopeciaSingapore Med JYear: 201051931621221497
14. Prasad DS,Kabir Z,Dash AK,Das BC. Prevalence and risk factors for metabolic syndrome in Asian Indians: A community study from urban Eastern IndiaJ Cardiovasc Dis ResYear: 201232041122923938
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16. Messenger AG,De Berker DA,Sinclair RD. Burns T,Breathnach S,Cox N,Griffiths CDisorders of hairRook's Textbook of DermatologyYear: 20108th edWest SussexWiley-Blackwell Publication66.1631
17. National cholesterol education program (NCEP) expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III)CirculationYear: 2002106314342112485966
18. Arias-Santiago S,Gutiérrez-Salmerón MT,Castellote-Caballero L,Buendía-Eisman A,Naranjo-Sintes R. Male androgenetic alopecia and cardiovascular risk factors: A case-control studyActas DermosifiliogrYear: 20101012485620398601
19. Agac MT,Bektas H,Korkmaz L,Cetin M,Erkan H,Gurbak I,et al. Androgenetic alopecia is associated with increased arterial stiffness in asymptomatic young adultsJ Eur Acad Dermatol VenereolYear: 2014
20. Arias-Santiago S,Gutiérrez-Salmerón MT,Buendía-Eisman A,Girón-Prieto MS,Naranjo-Sintes R. A comparative study of dyslipidaemia in men and woman with androgenic alopeciaActa Derm VenereolYear: 201090485720814623
21. González-González JG,Mancillas-Adame LG,Fernández-Reyes M,Gómez-Flores M,Lavalle-González FJ,Ocampo-Candiani J,et al. Androgenetic alopecia and insulin resistance in young menClin Endocrinol (Oxf)Year: 200971494919094069

Tables
[TableWrap ID: T1] Table 1 

Mean (SD) of demographic and laboratory parameters in AGA and control groups



[TableWrap ID: T2] Table 2 

Comparative proportions of MetS in AGA and control groups



[TableWrap ID: T3] Table 3 

Comparative proportions of MetS in various stages of AGA



[TableWrap ID: T4] Table 4 

Comparative proportions of individual components of MetS in AGA and control groups




Article Categories:
  • Original Article

Keywords: Androgenetic alopecia, case-control study, metabolic syndrome.

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