Document Detail

Association of polymorphonuclear leukocytes with sites of aortic catheter-induced injury in rabbits.
MedLine Citation:
PMID:  3675716     Owner:  NLM     Status:  MEDLINE    
The kinetics of the association of polymorphonuclear leukocytes (PMNs) with arterial balloon catheter-induced injury have been examined. An average of 6 X 10(7) PMNs were isolated from 20 ml of blood and labelled with 111In-oxine for reinfusion into the donor rabbit. The cells remained viable as demonstrated by both in vitro and in vivo tests of cell function. The abdominal aorta of rabbits was denuded of endothelium and immediately, 24 h, or 5 weeks later, exposed to autologous radiolabelled PMNs for 1 h. The presence of PMNs at sites of denudation was demonstrated by detection of the radioactive label and was confirmed by light and electron microscopy after 24 h, but not at 5 weeks. Immediately following denudation radioactivity was 2.44 +/- 0.33 times control (P = 0.006); 2.52 +/- 0.18 at 24 h (P = 0.005); and 1.88 +/- 0.32 times control at 5 weeks (P = 0.045). The presence of PMNs, or their products, 5 weeks after denudation suggests a more complex role of PMNs and possibly a direct involvement in the long term changes resulting from arterial balloon catheter injury.
C W Cole; P O Hagen; J F Lucas; E M Mikat; M K O'Malley; Z S Radic; R G Makhoul; R L McCann
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Atherosclerosis     Volume:  67     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1987 Oct 
Date Detail:
Created Date:  1987-11-24     Completed Date:  1987-11-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  229-36     Citation Subset:  IM    
Atherosclerosis Research Laboratory, Duke University Medical Center, Durham, NC 27710.
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MeSH Terms
Aorta, Abdominal / injuries
Blood Vessels / injuries*,  pathology
Endothelium, Vascular / physiology
Indium Radioisotopes / diagnostic use
Microscopy, Electron
Neutrophils / physiology*
Grant Support
Reg. No./Substance:
0/Indium Radioisotopes

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