Document Detail


Association of -634G/C and 936C/T polymorphisms of the vascular endothelial growth factor with spontaneous preterm delivery.
MedLine Citation:
PMID:  15059159     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: There is convincing evidence for a central role of vascular endothelial growth factor (VEGF) in fetal and placental angiogenesis. Our present study was undertaken to examine the possible relationship between two common functional VEGF gene polymorphisms (- 634G/C and 936C/T), linked with altered VEGF gene responsiveness, and spontaneous preterm delivery. METHODS: Genomic DNA was extracted from whole blood from 54 women with preterm labor and 79 menopausal women with at least two term spontaneous labors. DNA samples were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). RESULTS: Individuals with 936T/T or 936C/T genotype demonstrated a statistically significant association with preterm delivery compared with those sharing 936C/C genotype [P = 0.0009, risk factor 2.05, 95% confidence interval (CI) 1.37-3.06]. There were no significant associations between spontaneous preterm delivery and - 634 genotypes. CONCLUSION: An association was demonstrated between the VEGF 936C/T polymorphism and deliveries before 37 weeks of gestation.
Authors:
Dimitrios Papazoglou; Georgios Galazios; Michael I Koukourakis; Emmanuel N Kontomanolis; Efstratios Maltezos
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  83     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-02     Completed Date:  2004-05-13     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  461-5     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Medical School, Democritus University of Thrace, Patriarhou Grigoriou 97-99, 68100 Alexandroupolis, Greece. dapap@otenet.gr
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MeSH Terms
Descriptor/Qualifier:
Adult
Case-Control Studies
Female
Genotype
Humans
Middle Aged
Obstetric Labor, Premature / genetics*
Polymorphism, Genetic
Polymorphism, Restriction Fragment Length
Pregnancy
Vascular Endothelial Growth Factor A / genetics*
Chemical
Reg. No./Substance:
0/Vascular Endothelial Growth Factor A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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