Document Detail

Association of polymorphisms in exons 2 and 10 of the insulin-like growth factor 2 ( IGF2) gene with milk production traits in Polish Holstein-Friesian cattle.
MedLine Citation:
PMID:  19785908     Owner:  NLM     Status:  MEDLINE    
Insulin-like growth factor 2 (IGF2) is considered to be a regulator of post-natal growth and differentiation of the mammary gland. In the present work, associations of two single nucleotide polymorphisms in the bovine IGF2 gene with milk production traits were studied in dairy Holstein-Friesian cows: the already described g.8656C>T transition in exon 2 (RFLP-BsrI) and the newly found g.24507G>T transversion in exon 10 (RFLP-HaeIII), found by sequencing 273-bp exon 10 of the IGF2 gene in six individuals. Associations were analysed individually and in combination with the multi-trait repeatability test-day animal model. The CT/GT haplotype appeared to be associated with most of the milk traits studied (differences were significant at P < or = 0.001). The most frequent CT/GG haplotype seemed inferior to others in fat and protein content and daily yield of fat and protein but superior (together with the TT/GG genotype) when the daily milk yield is considered.
Emilia Bagnicka; Eulalia Siadkowska; Nina Strza?kowska; Beata Zelazowska; Krzysztof Flisikowski; J?zef Krzyzewski; Lech Zwierzchowski
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-09-29
Journal Detail:
Title:  The Journal of dairy research     Volume:  77     ISSN:  1469-7629     ISO Abbreviation:  J. Dairy Res.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-01-18     Completed Date:  2010-03-25     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985125R     Medline TA:  J Dairy Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
Institute of Genetics and Animal Breeding Polish Academy of Sciences, Jastrzebiec, Poland.
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MeSH Terms
Cattle / genetics*,  physiology
Exons / genetics
Fats / analysis
Haplotypes / genetics
Insulin-Like Growth Factor II / genetics*
Lactation / genetics*
Milk / chemistry
Milk Proteins / analysis
Polymerase Chain Reaction
Polymorphism, Genetic / physiology*
Polymorphism, Restriction Fragment Length
Polymorphism, Single Nucleotide / genetics
Quantitative Trait Loci / genetics
Reg. No./Substance:
0/Fats; 0/Milk Proteins; 67763-97-7/Insulin-Like Growth Factor II

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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