Document Detail


Association of polymorphisms in DNMT1, DNMT3A, DNMT3B, MTHFR and MTRR genes with global DNA methylation levels and prognosis of autoimmune thyroid disease.
MedLine Citation:
PMID:  23039890     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To clarify the association between factors regulating DNA methylation and the prognosis of autoimmune thyroid diseases (AITDs), we genotyped single nucleotide polymorphisms in genes encoding DNA methyltransferase 1 (DNMT1), DNMT3A, DNMT3B, methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (MTRR), which are enzymes essential for DNA methylation. Subjects for this study included 125 patients with Hashimoto's disease (HD), including 48 patients with severe HD and 49 patients with mild HD; 176 patients with Graves' disease (GD), including 79 patients with intractable GD and 47 patients with GD in remission; and 83 healthy volunteers (control subjects). The DNMT1+32204GG genotype was more frequent in patients with intractable GD than in patients with GD in remission. Genomic DNA showed significantly lower levels of global methylation in individuals with the DNMT1+32204GG genotype than in those with the AA genotype. The MTRR+66AA genotype was observed to be more frequent in patients with severe HD than in those with mild HD. The DNMT1+14395A/G, DNMT3B-579G/T, MTHFR+677C/T and +1298A/C polymorphisms were not correlated with the development or prognosis of AITD. Our study indicates that the DNMT1+32204GG genotype correlates with DNA hypomethylation and with the intractability of GD, and that the MTRR+66AA genotype may correlate with the severity of HD.
Authors:
Y Arakawa; M Watanabe; N Inoue; M Sarumaru; Y Hidaka; Y Iwatani
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  170     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-08     Completed Date:  2013-03-18     Revised Date:  2013-11-05    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  194-201     Citation Subset:  IM    
Copyright Information:
© 2012 Osaka University. Clinical and Experimental Immunology © 2012 British Society for Immunology.
Affiliation:
Department of Biomedical Informatics, Division of Health Sciences Department of Laboratory Medicine, Osaka University Graduate School of Medicine, Osaka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Child
DNA (Cytosine-5-)-Methyltransferase / genetics*
DNA Methylation*
Female
Ferredoxin-NADP Reductase / genetics*
Genotype
Graves Disease / enzymology,  genetics
Hashimoto Disease / enzymology,  genetics
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
Middle Aged
Polymorphism, Single Nucleotide
Prognosis
Thyroiditis, Autoimmune / enzymology,  genetics*
Young Adult
Chemical
Reg. No./Substance:
EC 1.18.1.-/methionine synthase reductase; EC 1.18.1.2/Ferredoxin-NADP Reductase; EC 1.5.1.20/MTHFR protein, human; EC 1.5.1.20/Methylenetetrahydrofolate Reductase (NADPH2); EC 2.1.1.37/DNA (Cytosine-5-)-Methyltransferase; EC 2.1.1.37/DNA (cytosine-5-)-methyltransferase 1; EC 2.1.1.37/DNA methyltransferase 3A; EC 2.1.1.37/DNA methyltransferase 3B
Comments/Corrections

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