Document Detail


Association of polymorphisms at the SR-BI gene locus with plasma lipid levels and body mass index in a white population.
MedLine Citation:
PMID:  10397692     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The scavenger receptor class B type I (SR-BI) is a lipoprotein receptor that has been shown to be important in high density lipoprotein cholesterol (HDL-C) metabolism in mice. To determine its role in humans, we have characterized the human SR-BI gene and investigated its genetic variation in 489 white men and women. Five variants were demonstrated: 2 in introns (3 and 5) and 3 in exons (1, 8, and 11). Three variants at exons 1 and 8 and intron 5 with allele frequencies >0.1 were used to examine associations with lipid or anthropometric variables. The exon 1 variant was significantly (P<0.05) associated with increased HDL-C and lower low density lipoprotein cholesterol (LDL-C) values in men, but no associations were observed in women. The exon 8 variant was associated in women with lower LDL-C concentrations (3.05+/-0.98 mmol/L and 3.00+/-0.93 mmol/L for heterozygotes and homozygotes, respectively) compared with women homozygous for the common allele (3.39+/-1.09 mmol/L, P=0. 043). No associations for this variant were observed in men. Women carriers of the intron 5 variant showed a higher body mass index (23. 8+/-3.8 kg/m2, P=0.031) than those women homozygous for the common allele (22.4+/-3.4 kg/m2). Similar results were observed after haplotype analysis. Multiple regression analysis using HDL-C, LDL-C, and body mass index as dependent variables and age, sex, and each of the genetic variants as predictors also provided similar results. The associations found with both LDL-C and HDL-C suggest that SR-BI may play a role in the metabolism of both lipoprotein classes in humans.
Authors:
S Acton; D Osgood; M Donoghue; D Corella; M Pocovi; A Cenarro; P Mozas; J Keilty; S Squazzo; E A Woolf; J M Ordovas
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  19     ISSN:  1079-5642     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-07-29     Completed Date:  1999-07-29     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1734-43     Citation Subset:  IM    
Affiliation:
Millennium Pharmaceuticals, Inc, Cambridge, MA, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antigens, CD36
Body Mass Index*
Chromosome Mapping
Female
Haplotypes
Humans
Lipids / blood*
Male
Membrane Proteins*
Middle Aged
Polymorphism, Genetic*
Receptors, Immunologic / genetics*
Receptors, Lipoprotein*
Receptors, Scavenger
Scavenger Receptors, Class B
Grant Support
ID/Acronym/Agency:
HL54776/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Antigens, CD36; 0/Lipids; 0/Membrane Proteins; 0/Receptors, Immunologic; 0/Receptors, Lipoprotein; 0/Receptors, Scavenger; 0/SCARB1 protein, human; 0/Scarb1 protein, mouse; 0/Scavenger Receptors, Class B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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