Document Detail


Association of the polymorphism of DR4 with the risk and severity of lumbar disc degeneration in the Chinese Han population.
MedLine Citation:
PMID:  23050498     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Death receptor 4 (DR4), an apoptosis-associated gene, plays an important role in the pathophysiology of lumbar disc degeneration (LDD). The present study aimed to determine whether the C626G polymorphism (rs4871857) of the DR4 gene is associated with the risk and severity of LDD in the Chinese Han population.
METHODS: A total of 296 patients with LDD and 208 healthy controls were enrolled in this study. The grade of disc degeneration was determined according to Schneiderman's classification for MRI. The C626G polymorphism of DR4 was genotyped using polymerase chain reaction and the restriction fragment length polymorphism method.
RESULTS: The genotype frequency of the C626G polymorphism was in agreement with the Hardy-Weinberg equilibrium (p = 0.194). The frequencies of the 626CG and GG genotypes were higher among LDD patients compared with normal controls; however, the differences were not significant. Patients with LDD showed significantly higher frequencies of the G allele than normal controls (p = 0.023). Unconditional logistic regression analysis revealed that the G allele was significantly associated with an increased risk of LDD compared with the C allele (p = 0.025; OR 1.958; 95% CI 1.087-3.526). However, no association was found between the different genotypes and the risk of LDD. In addition, the 626CG and GG genotypes, as well as the G allele were associated with higher degenerative grades of LDD compared with the CC genotype and the C allele, respectively (p = 0.005 and p < 0.001, respectively).
CONCLUSION: The C626G polymorphism of DR4 may be associated with the risk and severity of LDD in the Chinese Han population.
Authors:
Haitao Tan; Jinmin Zhao; Jianzhong Jiang; Yingang Ren
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  72     ISSN:  1502-7686     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-11     Completed Date:  2013-03-01     Revised Date:  2013-05-01    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  England    
Other Details:
Languages:  eng     Pagination:  576-9     Citation Subset:  IM    
Affiliation:
College of Postgraduate, Guangxi Medical University, Nanning, P.R China.
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MeSH Terms
Descriptor/Qualifier:
Base Sequence
China
DNA Primers
Ethnic Groups / genetics*
Genetic Predisposition to Disease
Humans
Intervertebral Disc Degeneration / genetics*,  pathology
Lumbar Vertebrae / pathology*
Polymerase Chain Reaction
Polymorphism, Genetic*
Receptors, TNF-Related Apoptosis-Inducing Ligand / genetics*
Severity of Illness Index
Chemical
Reg. No./Substance:
0/DNA Primers; 0/Receptors, TNF-Related Apoptosis-Inducing Ligand; 0/TNFRSF10A protein, human

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