| Association of a polymorphism of BTN2A1 with type 2 diabetes mellitus in Japanese individuals. | |
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MedLine Citation:
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PMID: 21672009 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIMS: We previously showed that the C→T polymorphism (rs6929846) of BTN2A1 was significantly associated with myocardial infarction in Japanese individuals by a genome-wide association study. Given that diabetes mellitus is an important risk factor for myocardial infarction, the association of rs6929846 of BTN2A1 with myocardial infarction might be attributable, at least in part, to its effect on susceptibility to diabetes. The purpose of this study was to examine the relation of rs6929846 of BTN2A1 to Type 2 diabetes mellitus. METHODS: A total of 8650 Japanese individuals from two independent subject panels were examined: Panel A comprised 1141 individuals with Type 2 diabetes and 3161 control subjects and panel B comprised 1664 individuals with Type 2 diabetes and 2684 control subjects. RESULTS: The chi-square test revealed that rs6929846 of BTN2A1 was significantly related to the prevalence of Type 2 diabetes in subject panel A (P = 0.0002) and subject panel B (P=0.006). Multivariable logistic regression analysis with adjustment for age, sex, body mass index and smoking status revealed that rs6929846 was significantly associated with Type 2 diabetes (P = 0.0006; odds ratio 1.25) in all individuals, with the T allele representing a risk factor for this condition. Multiple regression analysis with adjustment for age, sex and body mass index revealed that rs6929846 was significantly (P=0.04) related to blood glycosylated haemoglobin content in control subjects. CONCLUSIONS: BTN2A1 may be a susceptibility gene for Type 2 diabetes in Japanese individuals. |
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Authors:
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M Hiramatsu; M Oguri; K Kato; T Yoshida; T Fujimaki; H Horibe; K Yokoi; S Watanabe; K Satoh; Y Aoyagi; M Tanaka; H Yoshida; S Shinkai; Y Nozawa; T Murohara; Y Yamada |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Diabetic medicine : a journal of the British Diabetic Association Volume: 28 ISSN: 1464-5491 ISO Abbreviation: Diabet. Med. Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-10-18 Completed Date: 2012-01-03 Revised Date: 2012-02-29 |
Medline Journal Info:
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Nlm Unique ID: 8500858 Medline TA: Diabet Med Country: England |
Other Details:
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Languages: eng Pagination: 1381-7 Citation Subset: IM |
Copyright Information:
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© 2011 The Authors. Diabetic Medicine © 2011 Diabetes UK. |
Affiliation:
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Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Asian Continental Ancestry Group / genetics* Body Mass Index Case-Control Studies Chi-Square Distribution Diabetes Mellitus, Type 2 / complications, epidemiology, genetics* Female Genetic Predisposition to Disease Genome-Wide Association Study Genotype Humans Logistic Models Male Membrane Glycoproteins / genetics* Multivariate Analysis Myocardial Infarction / epidemiology, etiology, genetics* Odds Ratio Polymorphism, Single Nucleotide* Regression Analysis Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Membrane Glycoproteins; 0/butyrophilin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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