Document Detail


Association of platelet collagen receptor polymorphisms with premature acute myocardial infarction.
MedLine Citation:
PMID:  22627583     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The impact of platelet collagen receptor polymorphisms in the pathogenesis of myocardial infarction at young age remains unknown. To determine whether either of the two platelet collagen receptor polymorphisms (GP VI T13254C and GP Ia C807T) was associated with premature acute myocardial infarction. One hundred patients with premature acute myocardial infarction and 100 age-matched controls with normal coronary angiograms were studied. Genotyping was done using PCR followed by restriction fragment length polymorphism (RFLP). GP Ia C807T polymorphism was more frequent in the patient group (65%) than in the control group (53%). However, there was no association between this polymorphism and premature acute myocardial infarction (P = 0.08). The prevalence of T13254C polymorphism did not differ between patients (38%) and controls (33%), and this polymorphism was not associated with premature acute myocardial infarction (P = 0.46). Logistic regression analysis also indicated no association between these polymorphisms and premature acute myocardial infarction (C807T with P = 0.51 and T13254C with P = 0.20). There is no association between GP VI T13254C or GP Ia C807T polymorphisms and premature acute myocardial infarction.
Authors:
Ahmad Kazemi; Ahmad Fatemi; Nozar Givtaj; Mohammad Mehdi Peighambari
Related Documents :
8282433 - Effect of zinc deficiency on lipid peroxidation status and infarct size in rat hearts.
14751663 - Mice lacking osteopontin exhibit increased left ventricular dilation and reduced fibros...
2686933 - Incidence, physiologic description, compensatory mechanisms, and therapeutic implicatio...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-23
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  -     ISSN:  1473-5733     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
aDepartment of Hematology, School of Allied Medical Sciences, Tehran University of Medical Sciences bRajaie Cardiovascular Medical & Research Center, Tehran University of Medical Sciences cHerat Valve Disease Research Center, Rajaie Cardiovascular Medical & Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Alterations of sympathetic nervous system, coagulation and platelet function in gestational diabetes...
Next Document:  Does risk-based coagulation screening predict intraventricular haemorrhage in extreme premature infa...