Document Detail


Association of plasma osteoprotegerin levels with stroke severity and functional outcome in acute ischaemic stroke patients.
MedLine Citation:
PMID:  23030274     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Osteoprotegerin (OPG) is known to regulate processes involved in vascular injury and inflammation. We investigated the relationship between plasma OPG levels and stroke subtype, stroke severity at admission and functional outcome at 3 months in 172 patients with acute ischaemic stroke. Patients with large artery atherosclerosis and those with multiple causes had higher plasma OPG levels than patients with lacune. Increased plasma OPG levels were independently associated with more severe stroke and poor functional outcome. These results suggest pleiotropic roles of OPG in mediating atherosclerosis and ischaemic brain injury. OPG is a potential biomarker for predicting neurologic outcome in stroke.
Authors:
Tae-Jin Song; Jinkwon Kim; Seung-Hee Yang; Ji Hye Park; Hye Sun Lee; Chung Mo Nam; Ok-Hee Lee; Young Dae Kim; Hyo Suk Nam; Ji Hoe Heo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-3
Journal Detail:
Title:  Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals     Volume:  -     ISSN:  1366-5804     ISO Abbreviation:  Biomarkers     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9606000     Medline TA:  Biomarkers     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Neurology, Yonsei University College of Medicine , Seoul , Korea.
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