Document Detail


Association of plasma ω-3 and ω-6 lipids with burden of disease measures in bipolar subjects.
MedLine Citation:
PMID:  22884424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Omega-3 (n-3) fatty acids have been implicated in mood disorders, yet clinical trials supplementing n-3 fats have shown mixed results. However, the predominant focus of this research has been on the n-3 fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA). We used an unbiased approach to assay plasma n-3 and omega-6 (n-6) species that interact at the level of biosynthesis and down-stream processing, to affect brain function and, potentially, mood. We used lipomic technology to assay plasma levels of n-3 and n-6 fatty acids from 40 bipolar and 18 control subjects to investigate differences in plasma levels and associations with the burden of disease markers, neuroticism and global assessment of function (GAF) and mood state (Hamilton Depression Scale (HAM-D)). Most significantly, we found the levels of dihomo-gamma-linolenic acid (DGLA) to positively correlate with neuroticism and HAM-D scores and negatively correlate with GAF scores; and HAM-D to negatively correlate with linoleic acid (LA) and positively correlate with fatty acid desaturase 2 (FADS2) activity, an enzyme responsible for converting LA to gamma-linolenic acid (GLA). These associations remained significant following Bonferroni multiple testing correction. These data suggest that specific n-6 fatty acids and the enzymes that control their biosynthesis may be useful biomarkers in measurements of depressive disorders and burden of disease, and that they should be considered when investigating the roles of n-3s.
Authors:
Simon J Evans; Masoud Kamali; Alan R Prossin; Gloria J Harrington; Vicki L Ellingrod; Melvin G McInnis; Charles F Burant
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-08-11
Journal Detail:
Title:  Journal of psychiatric research     Volume:  46     ISSN:  1879-1379     ISO Abbreviation:  J Psychiatr Res     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-02     Completed Date:  2013-04-05     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  0376331     Medline TA:  J Psychiatr Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  1435-41     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Psychiatry, University of Michigan, Ann Arbor, MI 48109, USA. evanssi@umich.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Anxiety Disorders / blood,  enzymology
Biological Markers / blood
Bipolar Disorder / blood*,  enzymology
Fatty Acid Desaturases / blood
Fatty Acids, Omega-3 / biosynthesis,  blood*
Fatty Acids, Omega-6 / biosynthesis,  blood*
Female
Humans
Male
Middle Aged
Psychiatric Status Rating Scales
alpha-Linolenic Acid / blood
Grant Support
ID/Acronym/Agency:
1K01MH093708-01A1/MH/NIMH NIH HHS; DK089503/DK/NIDDK NIH HHS; K01 MH093708/MH/NIMH NIH HHS; P30 DK089503/DK/NIDDK NIH HHS; U24 DK097153/DK/NIDDK NIH HHS; UL1 RR024986/RR/NCRR NIH HHS; UL1RR024986/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 463-40-1/alpha-Linolenic Acid; EC 1.14.19.-/Fatty Acid Desaturases
Comments/Corrections

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