Document Detail


Association of plasma n-6 and n-3 polyunsaturated fatty acids with synovitis in the knee: the MOST study.
MedLine Citation:
PMID:  22353693     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In osteoarthritis (OA) the synovium is often inflamed and inflammatory cytokines contribute to cartilage damage. Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have anti-inflammatory effects whereas omega-6 polyunsaturated fatty acids (n-6 PUFAs) have, on balance, proinflammatory effects. The goal of our study was to assess the association of fasting plasma phospholipid n-6 and n-3 PUFAs with synovitis as measured by synovial thickening on contrast enhanced (CE) knee MRI and cartilage damage among subjects in the Multicenter Osteoarthritis Study (MOST). MOST is a cohort study of individuals who have or are at high risk of knee OA. An unselected subset of participants who volunteered obtained CE 1.5T MRI of one knee. Synovitis was scored in six compartments and a summary score was created. This subset also had fasting plasma, analyzed by gas chromatography for phospholipid fatty acid content, and non-CE MRI, read for cartilage morphology according to the Whole-Organ Magnetic Resonance Imaging Score (WORMS) method. The association between synovitis and cartilage morphology and plasma PUFAs was assessed using logistic regression after controlling for the effects of age, sex, and BMI. 472 out of 535 subjects with CE MRI had complete data on synovitis, cartilage morphology and plasma phospholipids. Mean age was 60 years, mean BMI 30, and 50% were women. We found an inverse relation between total n-3 PUFAs and the specific n-3, docosahexaenoic acid with patellofemoral cartilage loss, but not tibiofemoral cartilage loss or synovitis. A positive association was observed between the n-6 PUFA, arachidonic acid, and synovitis. In conclusion, systemic levels of n-3 and n-6 PUFAs which are influenced by diet, may be related to selected structural findings in knees with or at risk of OA. Future studies manipulating the systemic levels of these fatty acids may be warranted to determine the effects on structural damage in knee OA.
Authors:
K R Baker; N R Matthan; A H Lichtenstein; J Niu; A Guermazi; F Roemer; A Grainger; M C Nevitt; M Clancy; C E Lewis; J C Torner; D T Felson
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, N.I.H., Extramural     Date:  2012-02-04
Journal Detail:
Title:  Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society     Volume:  20     ISSN:  1522-9653     ISO Abbreviation:  Osteoarthr. Cartil.     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-04-09     Completed Date:  2012-06-12     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  9305697     Medline TA:  Osteoarthritis Cartilage     Country:  England    
Other Details:
Languages:  eng     Pagination:  382-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Boston University Clinical Epidemiology Research and Training Unit, Boston, MA 02215, United States. krbaker@bu.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Biological Markers / blood
Cartilage, Articular / pathology
Cohort Studies
Fatty Acids, Omega-3 / blood*
Fatty Acids, Omega-6 / blood*
Female
Humans
Magnetic Resonance Imaging / methods
Male
Middle Aged
Osteoarthritis, Knee / blood*,  complications,  pathology
Synovitis / blood*,  etiology,  pathology
Grant Support
ID/Acronym/Agency:
AR47785/AR/NIAMS NIH HHS; K23AR053855/AR/NIAMS NIH HHS; P60 AR047785/AR/NIAMS NIH HHS; R01 AR053161/AR/NIAMS NIH HHS; U01 AG018820/AG/NIA NIH HHS; U01 AG18820/AG/NIA NIH HHS; U01 AG18832/AG/NIA NIH HHS; U01 AG18947/AG/NIA NIH HHS; U01 AG19069/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6
Comments/Corrections

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