Document Detail

Association of plasma homocysteine and macular edema in type 2 diabetes mellitus.
MedLine Citation:
PMID:  18320515     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The aim of this study was to assess the association of macular edema (ME) with plasma homocysteine, vitamin B6, vitamin B12, and folic acid levels in patients with Type 2 diabetes. METHODS: Sixty-five diabetic subjects with no retinopathy and nonproliferative diabetic retinopathy (NPDR) (no DR, without ME, with ME: 16, 25, 24, respectively), 28 with proliferative diabetic retinopathy (PDR) (with and without ME: 14, 14, respectively), and 19 healthy subjects as control were recruited in this cross-sectional study. Plasma homocysteine, vitamin B12, vitamin B6, and folate levels were determined after 8-hour of fasting for all subjects. The levels of serum homocysteine and vitamin B6 were measured using high performance liquid chromatography (HPLC) with fluorescence detection, and the levels of serum vitamin B12 and folic acid were measured by electrochemiluminescence immunoassay. RESULTS: When diabetic groups with ME were compared with diabetic groups without ME for homocysteine, vitamin B12, vitamin B6, and folic acid, the only significant difference was detected in homocysteine levels (p=0.001). There was no significant difference between NPDR with ME group compared with NPDR without ME group and no DR group for plasma homocysteine, vitamin B12, vitamin B6, and folic acid (p=0.200, p=0.660; p=0.999, p=0.678; p=1.0, p=0.248; p=1.0, p=0.982, respectively). On the other hand, when PDR with ME group was compared with PDR without ME group, there was only significant difference in homocysteine levels (p=0.023). CONCLUSIONS: Mild to moderate elevation of homocysteine may explain the role of vascular dysregulation and endothelial dysfunction in patients with DR. The present study suggests hyperhomocysteinemia may be one of the crucial risk factors for development of ME.
E Aydin; H D Demir; H Ozyurt; I Etikan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of ophthalmology     Volume:  18     ISSN:  1120-6721     ISO Abbreviation:  Eur J Ophthalmol     Publication Date:    2008 Mar-Apr
Date Detail:
Created Date:  2008-03-05     Completed Date:  2008-06-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110772     Medline TA:  Eur J Ophthalmol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  226-32     Citation Subset:  IM    
Department of Ophthalmology, Gaziosmanpasa University Faculty of Medicine, Tokat, Turkey.
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MeSH Terms
Chemiluminescent Measurements
Chromatography, High Pressure Liquid
Cross-Sectional Studies
Diabetes Mellitus, Type 2 / blood*,  complications
Diabetic Retinopathy / etiology
Folic Acid / blood
Homocysteine / blood*
Hyperhomocysteinemia / blood,  complications
Macular Edema / blood*,  etiology
Middle Aged
Risk Factors
Vitamin B 12 / blood
Vitamin B 6 / blood
Reg. No./Substance:
454-28-4/Homocysteine; 59-30-3/Folic Acid; 68-19-9/Vitamin B 12; 8059-24-3/Vitamin B 6

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