Document Detail


Association of plasma eotaxin levels with the presence and extent of angiographic coronary artery disease.
MedLine Citation:
PMID:  16084515     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Eotaxin (CCL11) is an eosinophil-specific chemoattractant which has been found to be highly expressed at sites of vascular pathology. In the present study, we aimed to evaluate the association of plasma eotaxin levels with the presence and extent of angiographic coronary artery disease (CAD). Three hundred and fifty six consecutive patients attending for elective coronary angiography were investigated. Compared with 111 patients without CAD, 245 with CAD showed higher eotaxin concentrations [median (interquartile range): 76.0 (56.3-103.0)pg/ml versus 116.0 (80.5-162.0)pg/ml, respectively; P<0.001]. Importantly, a significant Spearman correlation was found between eotaxin levels and the extent score of coronary artery stenosis (r=0.449, P<0.001). A stepwise increase in plasma levels of eotaxin was also found depending on the number of >50% coronary stenosis: median value 76.0 pg/ml in CAD(-) subjects, 96.0 pg/ml in 1-vessel disease, 128.0 pg/ml in 2-vessel disease, and 129.0 pg/ml in 3-vessel disease (P<0.001 for trend). After confounding variables were controlled for, multiple stepwise regression analysis demonstrated that plasma eotaxin was an independent predictor of angiographic extent of CAD (beta=0.426, P<0.001). Our data suggest that increased eotaxin levels are associated with the presence of CAD and that circulating levels of this chemokine may reflect the extent of coronary atherosclerosis.
Authors:
Enzo Emanuele; Colomba Falcone; Angela D'Angelo; Piercarlo Minoretti; Maria P Buzzi; Marco Bertona; Diego Geroldi
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-09
Journal Detail:
Title:  Atherosclerosis     Volume:  186     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-03     Completed Date:  2006-09-12     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  140-5     Citation Subset:  IM    
Affiliation:
Interdepartmental Center for Research in Molecular Medicine (CIRMC), University of Pavia, Viale Taramelli 24, 27100 Pavia, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aged, 80 and over
Biological Markers
Chemokine CCL11
Chemokines, CC / blood*
Chemotactic Factors, Eosinophil / blood*
Coronary Angiography*
Coronary Disease / blood*,  radiography
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Retrospective Studies
Severity of Illness Index
Chemical
Reg. No./Substance:
0/Biological Markers; 0/CCL11 protein, human; 0/Chemokine CCL11; 0/Chemokines, CC; 0/Chemotactic Factors, Eosinophil

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