| Association of plasma PAF acetylhydrolase gene polymorphism with IMT of carotid arteries in Japanese type 2 diabetic patients. | |
MedLine Citation:
|
PMID: 12590019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The aim of this study was to investigate association of a missense mutation in plasma PAF acetylhydrolase (G994T) with intima media thickness (IMT) of the carotid arteries. One hundred and forty Japanese type 2 diabetic patients aged from 40 to 79 years without severe nephropathy were enrolled in this study. The genotype of the patients was determined by allele specific PCR. IMT of the carotid arteries of the subjects was recorded by B-mode ultrasound imaging. The patients were divided into two groups by genotyping, one carrying two wild alleles (wild group), and another carrying one or two mutant alleles (mutant group). Each group was further divided into two subgroups according to age; one subgroup consisted of 40s or 50s, and another consisted of 60s or 70s. The prevalence of the G994T mutation in the subjects was 28.6% (24.3% heterozygote, and 4.3% homozygote). IMT of the elderly patients of the mutant group was significantly greater (0.98 +/- 0.22 mm, n = 26) than of the elderly patients of the wild group (0.87 +/- 0.20 mm, n = 50, P = 0.0292). There was no significant difference in clinical characteristics between the two subgroups. The results of this study indicate that the missense mutation in plasma PAF acetylhydrolase is associated with development of atherosclerosis in the elderly. |
Authors:
|
Isamu Yamamoto; Junko Fujitsu; Shinpei Nohnen; Tsuyoshi Igarashi; Takashi Motomura; Makiko Inaba; Shoji Tsubakimori; Junichi Azuma |
Related Documents
:
|
834199 - Clinical and angiographic features of carotid transient ischemic attacks. 16391479 - Small artery dementia in japan: radiological differences between cadasil, leukoaraiosis... 6371889 - Intravenous dsa examination of patients with suspected cerebral ischemia. 11473749 - Lipid disorders and plaque imaging. 18345439 - Idiopathic inflammatory pseudotumor of the carotid sheath. 18694409 - Erectile haemodynamic status after radical prostatectomy correlates with erectile funct... 25030239 - Measurement of retinal function with flash-electroretinography in chinese patients with... 23828069 - Loss of consciousness and convulsion induced by a ventricular tachycardia mimicking epi... 3732429 - Bronchoalveolar lavage in patients with interstitial lung diseases: side effects and fa... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Diabetes research and clinical practice Volume: 59 ISSN: 0168-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2003 Mar |
Date Detail:
|
Created Date: 2003-02-18 Completed Date: 2003-09-29 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
|
Languages: eng Pagination: 219-24 Citation Subset: IM |
Copyright Information:
|
Copyright 2002 Elsevier Science Ireland Ltd. |
Affiliation:
|
Department of Clinical Evaluation of Medicines and Therapeutics, Graduate School of Pharmaceutical Science, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
1-Alkyl-2-acetylglycerophosphocholine Esterase Adult Aged Carotid Arteries / pathology* Carotid Artery Diseases / enzymology, genetics, pathology Diabetes Mellitus, Type 2 / enzymology, genetics*, pathology* Female Genotype Humans Japan Male Middle Aged Mutation, Missense Phospholipases A / blood*, genetics* Polymorphism, Genetic* Tunica Intima / pathology Tunica Media / pathology |
| Chemical | |
Reg. No./Substance:
|
EC 3.1.1.-/Phospholipases A; EC 3.1.1.47/1-Alkyl-2-acetylglycerophosphocholine Esterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical features of diabetes mellitus with the mitochondrial DNA 3243 (A-G) mutation in Japanese: m...
Next Document: Relative role of insulin resistance and beta-cell dysfunction in the progression to type 2 diabetes-...